29. Agents affecting bone mineral homeostatsis (calcium, vitamin D, parathyroid hormone, calcitonin, etc.)

Question 1

Which is the recombinant protein form of PTH?

Answer 1

Teriparatide

Question 2

Which drugs act as a calcitriol?

Answer 2

• Doxercalciferol
• Paricalcitol
• Calcipotriene

Question 3

Which are the principal hormonal regulators of bone mineral homeostasis?

Answer 3

• PTH
• Vitamin D
• FGF23

Question 4

Which are the secondary hormonal regulators of bone mineral homeostasis?

Answer 4

• Calcitonin
• Glucocorticoids
• Estrogen

Question 5

Which are the non-hormonal agents affecting bone mineral homeostasis?

Answer 5

• Bisphosphonates
  
  • Non-nitrogen-containing bisphosphonates:
    
    • Etidronate, clordronate, tiludronate
  • Nitrogen-containing bisphosphonates:
    
    • Alendronate**, risedronate, ibandronate, pamidronate, zoledronate
• Denosumab
• Cinacalcet
• Thiazides
• Fluoride
• Strontium ranelate

Question 6

What treatment strategies are there for osteoporosis?

Answer 6

• Hormone replacement therapy (estrogen)
• SERM (raloxifen)
• Bisphosphonates
• Denosumab
• Teriparatide
• Vitamin D and Ca²⁺