12. Drugs used for treatment of neurodegenerative disorders. Nootropic drugs

Question 1

Which are the drugs used for Parkinson’s disease?

Answer 1

• Drugs increasing DA effect:
  
  • ​Levodopa
  • Tolcapone, entacapone
  • Selegiline, rasagiline
• D2 agonists:
  
  • ​Ergot derivatives:
    
    • Bromocriptine
    • Cabergoline
  • Non-ergot derivatives:
    
    • Pramipexol
    • Ropirinol
    • Rotigotine
    • Apomorphine
• ACh decreasing drugs:
  
  • ​Benztropine, procyclidine, biperiden
  • Amantadine

Question 2

Which are the drugs used for Alzeihmer’s disease?

Answer 2

• AChE inhibitors:
  
  • ​Donepezil
  • Tacrine
  • Rivastigmine
  • Galantamine
• NMDA receptor antagonist:
  
  • Memantine

Question 3

Which are the drugs used for ALS?

Answer 3

Riluzole

Question 4

Which are the drugs used for Huntington’s disease?

Answer 4

• Baclofen, benzodiazepines
• Tetrabenazine
• Antipsychotics

Question 5

Which are the nootropic agents?

Answer 5

• Vasodilators:
  
  • ​Piracetam
  • Vinpocetin
  • Nicergolin
• Antioxidants:
  
  • ​Vitamin C
  • Vitamin E
  • Flavanoids
• Calcium channel antagonists:
  
  • ​Nimodipine
• Others:
  
  • ​NSAIDs
  • Estrogens
  • Trophic factors: Cerebrolysin, GDNF
  • Ampakins