6. 2nd generation (“atypical”) antipsychotic agents

Question 1

Which are the different groups of 2nd generation antipsychotics?

Answer 1

• Mixed antagonists (D₂ antagonist/5-HT_2A,C inverse agonist):
  
  • Tricyclic compounds (dibenzepines)
  • Other heterocyclic compounds
  • Partial agonists:
    
    • D₂ partial agonist, 5-HT₂ inverse agonist
    • D₃/D₂ partial agonist
• Selective antagonists:
  
  • D₂/D₃ antagonists

Question 2

Which are the tricyclic compounds?

Answer 2

• Clozapine
• Olanzapine
• Quetiapine

Question 3

Which are the other cyclic compounds?

Answer 3

• Risperidone
• Paiperidone
• Ziprasidone
• Lurasidone
• Sertindol
• Illoperidone

Question 4

Which are the D2 partial agonists/5-HT₂ inverse agonist?

Answer 4

Aripiprazole

Question 5

Which are the D2/D3 partial agonists?

Answer 5

Cariprazine

Question 6

Which are the selective D2/D3 antagonists?

Answer 6

• Sulpiride
• Tiapride
• Amisulpiride