31. Drugs used in the treatment of rheumatoid arthritis. Drugs used in chronic inflammatory bowel diseases (IBD). Flashcards
1
Q
What drug groups are used for treating RA?
A
- cs DMARDs
- ts DMARDS
- Non-DMARDs
- Biological agents
2
Q
Which are the cs DMARDs used to treat RA?
A
MALSCH:
- Methotrexate**
- Azathioprine
- Leflunomide
- Sulfasalazine
- Cyclosporin A
- Hydroxychloroquine
3
Q
Which are the ts DMARDs used to treat RA?
A
- Tofacitinib
- Baricitinib
4
Q
Which are the non-DMARDs used to treat RA?
A
- NSAIDs
- Corticosteroids
5
Q
Which are the biological agents used in RA?
A
- TNF alpha anatgonists:
- Adalimumab
- Certolizumab pegol
- Etanercept
- Golimumab
- Infliximab
- CTLA-4/Fc fusion protein:
- Abatacept
- IL-1 receptor antagonist:
- Anakinra
- IL-6 receptor inhibitor:
- Tocilizumab
- Sarilumab
- CD20 antagonist:
- Rituximab
6
Q
Which are the therapeutic approaches of mild IBD?
A
- 5-aminosalocylic acid (CD, UC)
- Locally applied glucocorticoids (UC)
- Budesonide (CD, UC)
7
Q
Which are the therapeutic approaches of moderate IBD?
A
- Oral glucocorticoids (CD, UC)
- Azathioprine/6-mercaptopurine (CD, UC)
- Methotrexate (CD)
8
Q
Which are the therapeutic approaches of severe IBD?
A
- IV glucocorticoids
- TNF alpha antagonists (infliximab, adalimumab, golimumab, …)
- Cyclosporins (UC)
- IL-12/IL-23 antagonists (ustekinumab) (CD)
- Integrin antagonist (natalizumab, vedolizumab) (CD)
- Surgery
9
Q
Which are the 5-aminosalicylic acid drugs for IBD?
A
- Sulfasalazine
- Mesalazine
- Olsalazine
10
Q
Which are the glucocorticoids used in IBD?
A
- Prednisolone
- Methylprednisolone
11
Q
Which are the cytotoxic drugs used in IBD?
A
- Azathioprine or 6-mercaptopurine (CD, UC)
- Methotrexate (CD)
12
Q
Which are the integrin inhibitor drugs used in IBD?
A
- Natalizumab
- Vedolizumab
