3.1.3 Soft Tissue Pathology I Flashcards
What is this?
Nodular fasciitis
Desmoid tumor is another name for what type of tumor?
Deep-seated fibromatosis
What is the diagnostic cell of rhabdomyosarcoma?
rhabdomyoblast also called “strap” cell
What are the general features of rhabdomyosarcoma?
Aggressive, txt w/ surg, rad, and chemo
What is the soft tissue tumor that is benign but grows quite rapidly?
Nodular fasciitis
Name for tumors of skeletal muscle?
rhabdomyoma, rhabomyosarcoma
What is the genetic variant of well-differentiated liposarcoma?
Amp of MDM2 oncogene
What are the diff names for tumor-like lesions of fibrous tissue?
Nodular fascitis, fibromatoses, fibrosarcoma
Does the nodular fasciitis recur after excision?
Rarely
What gene is involved in alveolar rhabdomyosarcoma?
FOXO1a gene
ID this tumor and the genetic variant
Liposarcoma, well-diffentiated
MDM2 amplification
What are the different names for tumors of fat?
Lipoma and liposarcoma
What is almost always found histologically in liposarcoma?
Lipoblasts (resembling fat fetal cells)
What type of tumor?
Superficial fibromatosis
What type of tumor? What are the arrows pointing at?
Rhabdomyosarcoma; strap cells
At what age do rhabdomyosarcomas occur?
Children
What is the genetic variant of myxoid/round cell (intermediate behavior) of liposarcoma?
Chromosomal abnormality t(12:16) (q13;p11)
Characteristics of what tumor?
Lipoma
What genetic mutation is often found in deep-seated fibromatosis (desmoid) tumor?
Beta-catenin
What type of soft tissue tumor?
Alveolar rhadomyosarcoma (this type of rhabdomyosarcoma lacks strap cells)
What type of tumor?
Fibrosarcoma - herring bone pattern
What type of tumor?
(deep seated)
Myxoid liposarcoma
What is the most common soft tissue sarcoma of childhood and adolescence (<20y/o)?
Rhabdomyosarcoma
What are the general features of soft tissue tumors?
What type of rhabdomyosarcoma is sarcoma boytroides?
Embryonal
Tumor?
Fibromatosis
Where does liposarcoma typically arise?
deep soft tissues of the proximal extremities and retroperitoneum
How are soft tissue tumors classified?
Based on the type of tissue that try to recapitulate
ID tumor
Nodular fasciitis (benign) - often palpable with poorly defined margin
Tumors of uncertain of histogenesis?
Synovial sarcoma (arise from anywhere but synovium)
Undifferentiated pleomorphic sarcoma (UPS)
What are the three histologic features of myxoid liposarcoma?
Myxoid background, vascular channels, and lipoblasts
Young woman w/ intra-abdominal mass, proliferating fibroblasts with abundant collagen. What type of tumor?
Desmoid tumor
What type of tumor
Fibrosarcoma
Which benign tumor?
Lipoma
What is the most common soft tissue tumor of adulthood?
Lipoma
