3.1.3 Soft Tissue Pathology I

Question 1

What is this?

Answer 1

Nodular fasciitis

Question 2

Desmoid tumor is another name for what type of tumor?

Answer 2

Deep-seated fibromatosis

Question 3

What is the diagnostic cell of rhabdomyosarcoma?

Answer 3

rhabdomyoblast also called “strap” cell

Question 4

What are the general features of rhabdomyosarcoma?

Answer 4

Aggressive, txt w/ surg, rad, and chemo

Question 5

What is the soft tissue tumor that is benign but grows quite rapidly?

Answer 5

Nodular fasciitis

Question 6

Name for tumors of skeletal muscle?

Answer 6

rhabdomyoma, rhabomyosarcoma

Question 7

What is the genetic variant of well-differentiated liposarcoma?

Answer 7

Amp of MDM2 oncogene

Question 8

What are the diff names for tumor-like lesions of fibrous tissue?

Answer 8

Nodular fascitis, fibromatoses, fibrosarcoma

Question 9

Does the nodular fasciitis recur after excision?

Answer 9

Rarely

Question 10

What gene is involved in alveolar rhabdomyosarcoma?

Answer 10

FOXO1a gene

Question 11

ID this tumor and the genetic variant

Answer 11

Liposarcoma, well-diffentiated

MDM2 amplification

Question 12

What are the different names for tumors of fat?

Answer 12

Lipoma and liposarcoma

Question 13

What is almost always found histologically in liposarcoma?

Answer 13

Lipoblasts (resembling fat fetal cells)

Question 14

What type of tumor?

Answer 14

Superficial fibromatosis

Question 15

What type of tumor? What are the arrows pointing at?

Answer 15

Rhabdomyosarcoma; strap cells

Question 16

At what age do rhabdomyosarcomas occur?

Answer 16

Children

Question 17

What is the genetic variant of myxoid/round cell (intermediate behavior) of liposarcoma?

Answer 17

Chromosomal abnormality t(12:16) (q13;p11)

Question 18

Characteristics of what tumor?

Answer 18

Lipoma

Question 19

What genetic mutation is often found in deep-seated fibromatosis (desmoid) tumor?

Answer 19

Beta-catenin

Question 20

What type of soft tissue tumor?

Answer 20

Alveolar rhadomyosarcoma (this type of rhabdomyosarcoma lacks strap cells)

Question 21

What type of tumor?

Answer 21

Fibrosarcoma - herring bone pattern

Question 22

What type of tumor?

(deep seated)

Answer 22

Myxoid liposarcoma

Question 23

What is the most common soft tissue sarcoma of childhood and adolescence (<20y/o)?

Answer 23

Rhabdomyosarcoma

Question 24

What are the general features of soft tissue tumors?

Answer 24

Question 25

What type of rhabdomyosarcoma is sarcoma boytroides?

Answer 25

Embryonal

Question 26

Tumor?

Answer 26

Fibromatosis

Question 27

Where does liposarcoma typically arise?

Answer 27

deep soft tissues of the proximal extremities and retroperitoneum

Question 28

How are soft tissue tumors classified?

Answer 28

Based on the type of tissue that try to recapitulate

Question 29

ID tumor

Answer 29

Nodular fasciitis (benign) - often palpable with poorly defined margin

Question 30

Tumors of uncertain of histogenesis?

Answer 30

Synovial sarcoma (arise from anywhere but synovium) Undifferentiated pleomorphic sarcoma (UPS)

Question 31

What are the three histologic features of myxoid liposarcoma?

Answer 31

Myxoid background, vascular channels, and lipoblasts

Question 32

Young woman w/ intra-abdominal mass, proliferating fibroblasts with abundant collagen. What type of tumor?

Answer 32

Desmoid tumor

Question 33

What type of tumor

Answer 33

Fibrosarcoma

Question 34

Which benign tumor?

Answer 34

Lipoma

Question 35

What is the most common soft tissue tumor of adulthood?

Answer 35

Lipoma