3. Mucosal Immunity Flashcards

1
Q

WHere is it most common to die from a mucosal infection?

A

GI tract

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2
Q

where is the 2nd most common place to die of a mucosal infection?

A

Respiratory tract

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3
Q

What are the 3 main components of Mucosal Tissues?

A

Epithelium
Lamina propria
Mucosal-asssociated lymph tissue (MALT)

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4
Q

What are some common cells found in the lamina propria of mucosal tissue?

A

TH1
TH17
Plasma cells and Memory B cells

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5
Q

Quick! what are the oral mucosal lymphoid tissues

A

Adenoid
Palatine
lingual

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6
Q

Do the mucosal infections follow traditional inflammatory cascade?

A

no they do not

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7
Q

how do most infections clear in the oral mucosa?

A

w/o inflammatory response

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8
Q

what responds in the mucosal immunity?

A

often local innate and adaptive cells (B and T cells)

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9
Q

What makes mucosal immunite unique anatomically?

A

closer interation w/ lymph system

peyer’s patches and isolated lymph things

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10
Q

what are some unique mucosal effector mechs? (4)

A

active memory T cells
regulatory T cells present
Secretory IgA
presence of distinctive microbiota

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11
Q

where are lymphocyctes activated in the mucosal tissue?

A

peyers patches

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12
Q

Where do you find Firmicutes?

A

1, Colon

2. Mouth

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13
Q

Two very important cells for mucosal immunity?

A

CD4

Th17

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14
Q

TGF-Beta is prominent where?

A

mucosal surfaces

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15
Q

Treg cells do what?

A

prevent inflammation

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16
Q

What do Th17 cells do?

A

Neutrophil recruitment
antimicrobial peptide production
tissue repair

17
Q

What cytokines do Th17 release?

A

IL-17

IL-22

18
Q

Impaired or Excessive Th17 is…

A

a sign of oral disease

19
Q

If there is too much IL-17 then

A

we have periodontitis

20
Q

if there is too few IL-17 then

A

Mucocutaneous candidiasis

21
Q

Which antibody is the most common in mucosal membranes?

A

IgA

22
Q

M cells expres what type of receptors?

A

TLR

NOD