3. Mucosal Immunity Flashcards
WHere is it most common to die from a mucosal infection?
GI tract
where is the 2nd most common place to die of a mucosal infection?
Respiratory tract
What are the 3 main components of Mucosal Tissues?
Epithelium
Lamina propria
Mucosal-asssociated lymph tissue (MALT)
What are some common cells found in the lamina propria of mucosal tissue?
TH1
TH17
Plasma cells and Memory B cells
Quick! what are the oral mucosal lymphoid tissues
Adenoid
Palatine
lingual
Do the mucosal infections follow traditional inflammatory cascade?
no they do not
how do most infections clear in the oral mucosa?
w/o inflammatory response
what responds in the mucosal immunity?
often local innate and adaptive cells (B and T cells)
What makes mucosal immunite unique anatomically?
closer interation w/ lymph system
peyer’s patches and isolated lymph things
what are some unique mucosal effector mechs? (4)
active memory T cells
regulatory T cells present
Secretory IgA
presence of distinctive microbiota
where are lymphocyctes activated in the mucosal tissue?
peyers patches
Where do you find Firmicutes?
1, Colon
2. Mouth
Two very important cells for mucosal immunity?
CD4
Th17
TGF-Beta is prominent where?
mucosal surfaces
Treg cells do what?
prevent inflammation
