1. B Cell-Mediated Immunity Flashcards
What chemokine attracts immature B cells to HEV?
CCL21
What chemokines attract B cells into lymph nodes?
CCL21
CCL19
What Chemokine attracts B cells into primary follicle?
CXCL13
Interatction with ____ and cytokines produces mature Naive B cells
follicular dendritic cells
Activation of B cells cause 3 things. what is it?
Clonal expansion
Class switching
Somatic hypermutation
What are the 2 antigen type signaling for B cell activation?
- Thymus-dependent
2. Thymus-independent
What are the three signals for B cell Activation?
- Antibody Crosslinking -activates
- Co-receptor - survival and proliferation
- Signaling
Cytokines - Differation, SHM, switch class
(1 & 2 are requisite)
When an Antibody is bound to an antigen (AKA Antibody crosslinking) what occurs? (3)
- Clustering/aggregation
- IGa and IGB signaling
- ITAM phosphorylation for recruitment
What does B Cell Co-receptor signaling ensure?
That the Target is pathogenic
What are the four roles of Cytokine Signaling?
- Survival and proliferation
- Class switching
- Somatic Hyper-mutation
- Differentiation
Naive T cells look for
Dendritic cells
Naive B cells look for
Follicular Dendritic cells found in the primary follicle
What is the most common B cell activation pathway?
TFH Cells Aid in B Cell Activation
Name the steps of TFH cell Aid in B Cell Activation. (4)
- B Cell binds to antigen
- B Cell presents to TFH
- CD40 induces proliferation and survival
- Cytokines cause Differantion and Isotype Switching
Where do Cognate pairs first move?
Primary Focus
What happens at the Primary Focus? (2)
- IgM expressing of plasma cells
2. No class switching nor hyper mutation
After the Primary Focus where do the cognate pairs move to and what occurs?
Secondary Focus to form Germinal Centers
What happens at 2nd Focus/ germinal Centers? (3)
- Proliferation & Plasma/memory cell production
- Class switching
- Selection of plasma cells
In Germinal centers cognate pairs form….?
Centroblasts
in the dark zone
Centroblasts create
centrocytes
What do Centroyctes form?
Plasma and B memory cells
in the light zone
Name somethings of Class switching (3)
- RAG activation
- change of Heavy chain
- Cytokine induced
What cell has a high- rate of Ig Secretion?
Plasma Cell
What are the 4 broad effector functions of Antiboies?
- Virus/toxin neutralization
- Opsonization
- Complement
- Antibody-dependent Cell-mediated CYtotoxicity (NK Cells)
What Antibodyies do you find in internal tissues?
IgM
IgG
IgA
What Antibodyies do you find in mucosal surfaces?
IgA
What Antibodyies do you find for parasite immunity?
IgE
What Antibodyies do you find for B cell receptor?
IgD
What does Fc receptors allow?
enhance innate immune cell specificity & function
What causes binding and unbinding of IgG w. FcRn?
pH lvls
Common antibodies for neutralizing pathogens?
IgA
IgG
Which antibodies Makes Mast Cells, Basophils and Eosinophils Competent?
IgE (important in allergies)
Which Antibodies initiate the Classical Complement pathway?
IgM
IgG
