3. Anifungal Drugs

Question 1

Fungi have____ which is composed of____

Answer 1

rigid cell walls

chitin

Question 2

Fungi cell membranes are composed of?

Answer 2

ergosterol

Question 3

What is the leading death of immunocompromised patients?

Answer 3

Pulmonary aspergillosis

Question 4

What is the primary drugs used for systemic fungal infections? (A.A.E.)

Answer 4

Amphotericin B
Azoles
Echinocandins

(target ergosterol synthesis)

Question 5

how does caspofungin kill fungi?

Answer 5

inhibit the wall synthesis

Question 6

How does naftifine and terbinafine work?

Answer 6

by preventing ergosterol synthesis

this needs fine work to be made

Question 7

how does Amphotericin B and nystatin work?

Answer 7

disrupt membrane

Question 8

how do axoles work?

Answer 8

prevent ergostarol synthesis

Question 9

how does one absorbe Amphotericin B?

Answer 9

parenteral IV

Question 10

What is a side effect of Amphotericin B?

Answer 10

renal toxicity

nuerotoxicity

Question 11

how does one absore Nystatin?

Answer 11

topical

DO NOT PUT THIS IN THE SYSTEM!

Question 12

Do not give azole during____?

Answer 12

pregnancy lactation or hepatic issues

Question 13

What is more toxic than Fluconazole?

Answer 13

Itraconazole

Question 14

Should Ketoconozale and Amphotericin B be co-administraded?

Answer 14

NEVER

Question 15

What is an adverse effect of Flucytosine?

Answer 15

bone marrow suppression

Question 16

Flucytosine inhibits what?

Answer 16

DNA/RNA synthesis

Question 17

Echinocandins when don’t you give it?

Answer 17

to pregnant people

Question 18

When should you give Caspofungin?

Answer 18

just in an extreme “case”

Question 19

What has replaced Griseofulvin?

Answer 19

Terbinafine

Question 20

adverse effects of griseofulvin?

Answer 20

Teratogenic, headaches, carcinogenic