3: Gynecologic Cancers Treatment

Question 1

• Surgery alone usually cures local disease.
• Patients with myometrial invasion usually have surgery and radiation.

Answer 1

Endometrial cancer

Question 2

• Surgical treatment available for stages I-IIA.
• Chemoradiation

Answer 2

Cervical cancer

Question 3

• Surgery (hysterectomy and salpingo-oophorectomy with omentectomy).
• Stages 2-4 treated with surgical debulking plus chemotherapy.

Answer 3

Ovarian cancer

Question 4

• Surgical resection is the standard treatment.
• Imiquimod or chemotherapeutic agents (5-FU) may be used if disease is not invasive.
• Laser an option for precancerous lesions.
• Radical excision with lymph node removal may be required in stages 3-4.

Answer 4

Vulvar cancer

Question 5

• The combination of paclitaxel, doxorubicin, and cisplatin has been shown to significantly improve response rates in women with advanced or recurrent cancer, although neurotoxicity is a significant problem for many patients.
• Paclitaxel in conjunction with carboplatin is less toxic and is an alternative regimen

Answer 5

Endometrial cancer

Question 6

Options include:

• Surgery (total hysterectomy with salpingo-oophorectomy and peritoneal washing)
• Radiation
• Chemotherapy
• Hormonal therapy (progestational drugs)
• Biologic therapy

Answer 6

Endometrial cancer