3/14/17

Question 1

Hep A Vector

Answer 1

Fecal-Oral: Contaminated water (i.e. shellfish)

Question 2

Insulin: Processing pathway

Answer 2

PreProInsulin (Rough ER) > ProInsulin (RER) > ProInsulin (golgi) > ProInsulin (Secretory Granule) > Insulin + C pep (Secretory Granule)

Question 3

Pulm Trunk vs Right Atrium

Answer 3

Pulm: 2nd intercostal

RA 4th

Question 4

Coag dysfunction: Crohns pathophys

Answer 4

Crohns leads to decreased bile acid reabsorption, leading to fat soluble vitamin lost (A,D,E,K), Loss of K leads to Coag dysfunction

Question 5

South-Western Blott

Answer 5

DNA-binding Proteins (such as c-jun and c-fos)

Question 6

Buproprion: Side Effects on anorexics

Answer 6

Seizures

Question 7

Cystic Fibrosis: CTFR role

Answer 7

ATP-binding chloride channel

Question 8

Schizo affective vs schizo

Answer 8

schizo-affective: schizo + mood symps

Question 9

Patau Syndrome: Signs and Symps

Answer 9

Round punched out head lesions (cutis aplasia), polydactyly, renal defects, heart defects, umbilical herniation (omphalocele), rocker-bottom feet, midline defects (micro/holoprosencephaly, microphthalmia, cleft palete/lip)

Question 10

Major Depression vs Adjustment: Differential

Answer 10

If 5 of 9 criteria for major depression met, overrides adjustment

Question 11

Foreign Body Rejection: Histo

Answer 11

Granulomatous Formation (macrophage/inflammation with central necrosis)

Question 12

Restrict Cardiomyopathy: Histo + Signs

Answer 12

Histo: Endocardial thickening with noncompliant vents

Signs: CHF

Question 13

Sensorineural vs Conductive hearing loss: Rine and Weber Tests

Answer 13

Sensorineural:
Rine: Air conduction > bone conduction bilateral
Weber: Goes to unaffected ear

Conductive:
Rine: AC > BC unaffected, BC > AC affected
Weber: Goes to affected ear

Question 14

Multiple endocrine Neoplasia: types

Answer 14

I: Primary hyperparathroidism, pituitary, pancreatic
IIA: Medullary thyroid (Calcitonin) , pheo, parathyroid hyperplasia
IIB: Medullary thyroid, pheo, mucosal neruomas/mafanoid

Question 15

Cystic Fibrosis: Longterm support

Answer 15

Pancreatic Lipase due to pancreatic insufficiency

Question 16

Alteplase: MoA

Answer 16

Clot buster via entangled plasminogen activator

Question 17

Gestational DM: inheritable predisposition

Answer 17

Deficiency in glucokinase (beta cell sensor protein)

Question 18

IL-8 function

Answer 18

Neutrophil Chemotaxis

Question 19

Arteriole Dilation: Sympathetic response

Answer 19

Cardiac: HR, CO, Contractility up
RAAS: salt and water retention

Question 20

C1 elastase inhibitor action

Answer 20

Complement and Bradykinin supressor

Question 21

Alpha-1 Antitrypsin deficiency: association

Answer 21

Total Lung Capacity Up, FEV/FVC ratio down, diffusing capacity down (due to decreased elasticity/COPD)`

Question 22

Lymph drainage: Rectal

Answer 22

Internal Illiac

Question 23

Brief Psychotic Disorder

Answer 23

> 1 day, <1mo, return to function

Question 24

Piriformis Syndrom: Signs and Symps + Pathophys

Answer 24

Signs: pain, numbness, tenderness to palp/internal rotation/adduction

piriformis compression of sciatic nerve

Question 25

Keratin associated hyper/dysplasias: progression

Answer 25

progress to squamous cell carcinoma

Question 26

Nucleolus: histo

Answer 26

dark, basophilic, dense, in nucleus

Question 27

Acute Pancreatits: Histo

Answer 27

Fat necrosis and calcifications

Question 28

HPV Infection: tissue type

Answer 28

Stratified Squamous Epithelium (such as true vocal cords - weak cry, stridor, hoarseness)

Question 29

EBV: ring enhancing lesions

Answer 29

Primary CNS Lymphoma

Question 30

Cervical abnormalities: important risk factor

Answer 30

Barrier contraceptive/HPV vacc

Question 31

K reabsorption in Kidney:

Answer 31

Collecting Duct