26. Epigenetics of Heart Failure Flashcards

1
Q

DNA acetylation (and other modifications) occurs on the ____ residues.

A

lysine

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2
Q

____ extend beyond the nucleosome and are sites of post-translational modification.

A

Histone tails

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3
Q

What does HDC stand for?

A

histone deacetylase

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3
Q

____ Stimulates Cardiac Hypertrophy in Mice.

A

HDAC9 Gene Knockout

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4
Q

What is the histone code?

A

a code read by proteins; consists of all the histone modifications; determines whether RNA pol II engages with DNA

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4
Q

HDAC9 Overexpression Blocks _______.

A

Cardiomyocyte Hypertrophy

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5
Q

_____ are good drug targets.

A

The enzymes that regulate epigenetic processes

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6
Q

What is the octameric,, basic unit of chromatin called?

A

a nucleosome

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8
Q

The hallmarks of cardiac hypertrophy are ____, ____, and ____.

A

new protein synthesis sarcomere assembly gene expression

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9
Q

Name 3 ways gene expression can be altered w/o changing the DNA sequence.

A
  1. histone modifications 2. chromatin remodling 3. DNA methylation
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9
Q

Epigenetic marks are created and controlled by ____.

A

enzymes

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9
Q

HDAC9 Gene Knockout Stimulates _____ in Mice.

A

Cardiac Hypertrophy

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11
Q

What does a HAT do?

A

write the histone code by adding acetyl groups to lysines- turns genes on

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12
Q

The enzymes that regulate epigenetic processes are good ____.

A

drug targets

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15
Q

What is chromatin?

A

DNA + histones (proteins)

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16
Q

Abnormal epigenetics can contribute to the development of ______, such as ____.

A

cardiomyopathy; cardiac hypertrophy

17
Q

_____ Overexpression Blocks Cardiomyocyte Hypertrophy.

A

HDAC9

18
Q

What does HAT stand for?

A

histone acetyltranferase

19
Q

What does an HDC do?

A

erases the histone code by deleting the acetyl groups from lysines- turns gene off

20
Q

DNA methylation occurs on ____ residues of _____ dinucleotides.

A

cystosine; CpG