26. Epigenetics of Heart Failure Flashcards
DNA acetylation (and other modifications) occurs on the ____ residues.
lysine
____ extend beyond the nucleosome and are sites of post-translational modification.
Histone tails
What does HDC stand for?
histone deacetylase
____ Stimulates Cardiac Hypertrophy in Mice.
HDAC9 Gene Knockout
What is the histone code?
a code read by proteins; consists of all the histone modifications; determines whether RNA pol II engages with DNA
HDAC9 Overexpression Blocks _______.
Cardiomyocyte Hypertrophy
_____ are good drug targets.
The enzymes that regulate epigenetic processes
What is the octameric,, basic unit of chromatin called?
a nucleosome
The hallmarks of cardiac hypertrophy are ____, ____, and ____.
new protein synthesis sarcomere assembly gene expression
Name 3 ways gene expression can be altered w/o changing the DNA sequence.
- histone modifications 2. chromatin remodling 3. DNA methylation
Epigenetic marks are created and controlled by ____.
enzymes
HDAC9 Gene Knockout Stimulates _____ in Mice.
Cardiac Hypertrophy
What does a HAT do?
write the histone code by adding acetyl groups to lysines- turns genes on
The enzymes that regulate epigenetic processes are good ____.
drug targets
What is chromatin?
DNA + histones (proteins)
