225- prostate histo Flashcards

1
Q

histology of BPH

A

2 cell layers thick in the glands (as opposed to CA which has no basal layer)

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2
Q

what is the main type of prostate cancer? what drives it? what race? precursor lesions?

A

adenocarcinoma. Androgen dependent. African Americans.

Prostatic Intraepithelial neoplasia (PIN): retains basal layer (cancer loses basal layer and invades)

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3
Q

histo changes in cancer

A

presence of acinar nucleoli, smaller glands, absence of basal cells, greater N:C ratio

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4
Q

staining of high grade PIN vs cancer

A

HGPIN has more racemase and less p63?

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5
Q

what is gleason grading based on

A

based on architecture pattern, ignores cytologic features. You add the two (1-5) scores from each pattern and get a sum score from 2-10

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