208- benign and malignant uterus Flashcards

1
Q

when do leiomyomas first begin to develop

A

when you reach repro age (they are estrogen dependent). Start to go away after menopause

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2
Q

what do you see in histology of leiomyoma? What factor is increased? What other abnormalities

A

increase extra cellular matrix relative to myometrium.
THF beta
40% have chromosomal abnormalities

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3
Q

what is the pathophys of leiomyoma

A

neoplastic transformation of single cell which undergoes monoclonal expansion

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4
Q

relation of progesterone to leiomyoma

A

increased so it provides therapeutic target

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