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2nd Year - Pathology > 2.06 Skin Pathology > Flashcards

2.06 Skin Pathology Flashcards

1
Q

Sebaceous glands, hair follicles, and sweat glands are contained in what layer of the skin

A

Dermis

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2
Q

What is the characteristic histologic appearance of squamous cell carcinoma

A

keratin pearls

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3
Q

Risk factor for malignant melanoma

A

Sun exposure

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4
Q

Most common malignant skin tumor

A

Basal cell carcinoma

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5
Q

Cell of origin of basal cell carcinoma

A

Keratinocyte precursor in the basal cell layer

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6
Q

Melanocytic hyperplasia of the basal layers of the epidermis; clinical presentation is a brown pigmented spot on the skin

A

Lentigo

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7
Q

This occurs due to an increase in the number of melanocytes that form clusters

A

Melanocytic Nevi

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8
Q

in comparing junctional nevus from dermal nevus, junctional nevus is appears ___ (pigmentaiton and elevation)

A

Junctional nevus: less pigmented, generally flat

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9
Q

in comparing junctional nevus from dermal nevus, dermal nevus is appears ___ (pigmentaiton and elevation)

A

dermal nevus: more pigmented and elevated

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10
Q

Urticaria is due to what type of hypersensitivity

A

Hypersensitivity Type I, IgE mediated

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11
Q

Acute Eczematous Dermatitis is due to what type of hypersensitivity

A

Hypersensitivity Type IV

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12
Q

What is the characteristic gross lesion of erythema multiforme

A

Target lesion

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13
Q

Severe for of erythema multiforme; febrile, often in children, with extensive involvement of the skin and mucosal surfaces; epidermal detachment is less that 30%

A

Steven Johnson syndrime

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14
Q

Severe for of erythema multiforme with diffuse necrosis and peeling of skin and mucosal surfaces

A

Toxic epidermal necrolysis

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15
Q

This condition is characterized by the hyperproliferation of epidermis and abnormal keratinization due to faster turnover time of epidermal keratinocytes; there is accumulation of cells in the stratum corneum that leads to scaling

A

Psoriasis

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16
Q

Psoriasis is usually found in what areas of the body

A

Extensor surfaces of the elbows, knees
Scalp
Lumbosacral areas

17
Q

__ sign is the punctate bleeding seen when capillary loops are exposed when the epidermis is scratched in patients with psoriasis

A

Auspitz sign

18
Q

Test tube appearance in psoriasis is due to ___

A

elongation of rete pegs

19
Q

6 P’s of Lichen Planus

A

Pruritic, purple, polygonal, planar, papules and plaques

20
Q

Typical locations of lichen planus

A

Flexor surfaces
inner chest
genitalia
buccal mucosa

21
Q

Histologic appearance of lichen planus

A

bandlike infiltration of lymphocytes at the dermoepidermal junction, hyperkeratosis, and saw tooth pattern of rete pegs

22
Q

Location of seborrheic dermatitis

A

Regions with high density of sebaceous glands (forehead, scalp, external auditory canal)

23
Q

Gross clinical presentation of seborrheic dermatitis

A

macules and papules on an erythematous-yellow, greasy base, with scaling and crusting, fissures, dandruff,

24
Q

__ is a blistering disorder caused by autoantibodies that result in the dissolution of intercellular attachments within the epidermis and mucosal epithelium

A

Pemphigous

25
Q

State the pathology and lesion involved in pemphigus vulgaris

A

Etiology: Autoantibodies (IgG) against Dsg1 and Dsg3
Acantholysis with intraepidermal bullae
Lesion: blisters in the deep suprabasal epidermis

26
Q

State the etiology and lesion found in pemphigous foliaceus

A

Etiology: Autoantibodies against Dsg1 alone
Lesion: superficial subcorneal blisters

27
Q

State the etiology and lesion in bullous pemphigoid

A

Etiology: Autoantibodies bind BPAG2 ( component of the hemidesomes)
Lesion: blister formation at the level of the lamina lucida of the BM.

28
Q

State the pathogenesis and lesion involved in dermatitis herpetiformis

A

IgA antibodies are developed against dietary gluten. the antibodies cross-react with reticulin (component of fibrils that anchor hemidesmosomes to the dermis) leading to early dermoepidermal separation
Lesion: subepidermal blister

29
Q

Appearance of epidermolysis bullosa

A

blisters at sites of pressure, rubbing or trauma, or in flexural creases

30
Q

Location of lesions of dematitis herpetiformis

A

Bilateral symmetric and grouped vesicles at extensor surfaces, elbows, knees

31
Q

Acute dermatosis is characterized primarily by infiltration of ___

A

lymphocytes and macrophages

32
Q

What is the severe form of erythema multiforma which is usually in febrile form in children, with extensive involvement of skin and mucosal surfaces, epidermal detachment occuers in less than 10% of cases

A

Steven Johnson Syndrome

33
Q

Characterize lesion and location of lesion in psoriasis

A

Epidermal hyperplasia, parakeratotic scale, and accumulation of neutrophils within the superficial epidermis
Located in extensor surfaces of elbows and knees, scalp, and lumbosacral areas

34
Q

Lichen planus is located at___

A

the flexor surfaces and inner chest, genitalia, and buccal mucosa

35
Q

Appearance of immunofluorescence of pemphigous vulgaris

A

chicken-wire appearance or netlike pattern of intercelllar IgG deposits along the plasma membranes of epidermal keratinocytes, which shows suprabasal separation

36
Q

Appearance of immunofluorescence of bullous pemphigoid

A

Antibody deposition occurs in a continuous linear (ribbon-like) pattern at the dermoepidermal junction

37
Q

Patients with celiac disease develop IgA antibodies that react to reticulin which a component of fibrils that anchor hemidesmosomes which leads to ___ in ___ disease

A

dermoepidermal separation in DERMATITIS HERPETIFORMIS

38
Q

State pathology in pemphigous vulgaris

A

acantholysis with intraepidermal bullae, atnibodies to keratinocyte antigens which are involved in intercellylar attachment
Lesion: blisters in the deep suprabasal epidermis

39
Q

Identify lesion: intercellular edema of epidermis resulting to increased space between keratinocytes; elongated
intercellular bridges

A

Spongiosis

2nd Year - Pathology (9 decks)

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