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2nd Year - Pathology > 2.02 Disease Of Immunity > Flashcards

2.02 Disease Of Immunity Flashcards

1
Q

Substances produced by T lymphocytes in cell-mediates immunity

A

Cytokines and leukotrienes

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2
Q

T lymphocytes are found in the ___ areas of the lymph nodes and in the __ areas of the spleen

A

Paracortical areas of lymph node

Peroarterioler areas of the spleen

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3
Q

Surface markers present in suppressor T cells

A

Pan T markers: CD3,2,5

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4
Q

Subtype of helper t cells that stimulate production of most opsonizing and complement fixing bodies

A

TH1

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5
Q

Subtype of t helper cells that secrete cytokines that stimulate the production of IgE and activate eosinophils

A

TH2

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6
Q

Major cytokine that activates macrophages

A

Interferon

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7
Q

what is the most important APC for initiating prinary immune response

A

Dendritic cells

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8
Q

What are immature dendritic cells within the epidermis

A

Langerhans cells

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9
Q

Receptors and MHC class of helper t cells

A

CD4

MHC Class II

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10
Q

What is the major cytokine that activates macrophages

A

Interferon

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11
Q

What is the most important antigen presenting cell

A

Dendritic cells

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12
Q

Morphologic name of NK cells

A

Large granular lymphocytes

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13
Q

Cell surface molecules in NK cells that gives the ability to lyse IgG coated target cells

A

CD16 cell surface molecules

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14
Q

Adaptive immunity that acts in intracellular microbes

A

Cell mediated immunity

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15
Q

__ immunity develops responses to soluble antigens

A

Humoral immunity

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16
Q

__ immunity develops responses to insoluble antigens

A

Cell mediated immunity / cellular immunity

17
Q

What cytokine activates and initiates proliferation of naive T cells

A

IL-2

18
Q

What is the critical event in anaphylaxis that leads to degranulation of the maat cell

A

Bridging of IgE

19
Q

Most potent eosinophil activator (interleukin)

A

IL-5

20
Q

___ immunity develops a response to soluble antigens

A

Humoral immunity

21
Q

__ immunity develops a response to insoluble antigens

A

Cellular immunity (cell-mediated immunity)

22
Q

What cytokine initiates the activation and proliferation of T cells

A

IL-2

23
Q

What kind of test would you request if you are asking for MHC Class I?

A

Simple serologic assay

24
Q

What kind of test would you request if you are asking for MHC class II?

A

Mixed lymphocyte assay

25
Q

SLE is associated with HLA __ and __

A

HLA Dr-2

HLA Dr-3

26
Q

Drugs that can produce drug-induced SLE

A

Procainamide
Hydralazine
Isoniazid
D-Panicillamine

27
Q

The benign form of progressive systemic sclerosis

A

Limited scleroderma or CREST syndrome

28
Q

CREST Syndrome is serologically suggested by presence of

A

Anti-centromere antibodies

29
Q

Features of CREST syndrome

A 
Calcinosis
Reynaud's phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasis
30
Q

Main microscopic feature jn scleroderma

A

Fibrosis

31
Q

Antibody specific for diffuse scleroderma

A

Scl-70

32
Q

Pathognomonic sign in poliomyosistis-dermatomyosistis

A

Heliotropic rash

33
Q

Most specific antibody for Sjorgen’s syndrome

A

Anti-SS-A

Anti-SS-B

34
Q

Anatomic structures that may be aplastic or hypoplastic in DiGeorge syndrome

A

Thymus
Parathyroid
Great vessels
Esophagus

35
Q

___ immunity develops a response to soluble antigens

A

Humoral immunity

36
Q

__ immunity develops a response to insoluble antigens

A

Cellular immunity (cell-mediated immunity)

37
Q

What cytokine initiates the activation and proliferation of T cells

A

IL-2

38
Q

Triad of features of ataxia telangiectasia

A

Cerebellar ataxia
Mucocutaneous telangiectasias
Recurrent respiratory tract infections

39
Q

Where is the genetic defect located in Ataxia Telangiectasia

A

Long arm of chromosome 11

2nd Year - Pathology (9 decks)

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