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Pharmacology > 2 Treatment of Coagulation Disorders and Hyperlipidemia > Flashcards

2 Treatment of Coagulation Disorders and Hyperlipidemia Flashcards

1
Q

What do you call inadequate clotting?

A

Hemorrhage

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2
Q

What do you call excessive clotting?

A

Thrombogenesis

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3
Q

Clotting factors are

________________ synthesized in the ______

A

proteolytic enzymes synthesized in the liver

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4
Q

____________ damage begins a cascade effect

A

Blood vessel

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5
Q

Intrinsic system: begins when ___________ contacts damaged vessel

A

factor XII (12)

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6
Q

Extrinsic system: begins when damaged vessel releases …

A

tissue factor (thromboplastin)

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7
Q

Drugs for over active clotting

A
  • Anticoagulants
  • Antithrombotics
  • Thrombolytics
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8
Q

Anticoagulants are used primarily in …

A

venous thrombosis

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9
Q

What is the primary anticoagulant prescribed to treat venous thrombosis

A

Heparin

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10
Q

What are the types of heparin?

A

Unfractionated heparin and low molecular weight heparin

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11
Q

How is unfractionated heparin administered?

A

IV

Several times a day

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12
Q

Which is more predictable, unfractionated heparin or low molecular weight heparin?

A

Low molecular weight heparin

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13
Q

How is low molecular weight heparin administered?

A

Sub-Q

Once a day

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14
Q

True or false; heparin can increase platelets

A

False, decrease

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15
Q

What is the difference between Type I and Type II Heparin-induced thrombocytopenia?

A

Type I

  • asymptomatic
  • resolves spontaneously

Type II

  • immune reaction resulting in thrombosis
  • life or limb threatening
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16
Q

What is the primary drug given as an anticoagulant, especially for A fib or valve surgery?

A

Coumadin (warfarin)

17
Q

True or false; antithrombotic drugs prevent thrombus formation in central veins

A

False; peripheral

18
Q

Hemophilia A – Deficiency in …

A

clotting factor VIII

19
Q

Hemophilia B – Deficiency in …

A

clotting factor IX

20
Q

What is the primary concern with anticlotting drugs?

A

Hemorrhage

21
Q

What is the treatment for hyperlipidemia?

A

Statins

Pharmacology (24 decks)

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