2 Gastrointestinal Drugs

Question 1

What do antacids do?

Answer 1

• chemically neutralize stomach acids
• used to treat indigestion and heart burn
• primarily used to treat minor and transient dyspepsia

Question 2

What are the adverse effects of antacids?

Answer 2

• Acid rebound phenomenon (Calcium)
• Alter absorption of electrolytes
• Alter metabolism of other medications
• Constipation
• Diarrhea
• Cause changes in urinary pH affecting drug elimination

Question 3

What does histamine do?

Answer 3

Histamine stimulates specific receptors in the stomach lining to increase gastric acid secretion

Question 4

True or false: histamine receptor blockers activate receptors when they bind to them

Answer 4

False.

Question 5

What are histamine receptor blockers prescribed for?

Answer 5

Peptic ulcer and GERD

Question 6

What are the adverse effects of histamine receptor blockers?

Answer 6

Well tolerated
Headache
Arthralgia
Tolerance
Myalgia
Mild GI problems
Dizziness

Question 7

What is a proton pump inhibitor trying to inhibit?

Answer 7

H+, K+ and ATP enzyme (proton pump) which are responsible for secreting acid from gastric parietal cells into the lumen of the stomach

Question 8

Proton pump inhibitors _________ gastric acid secretions

Answer 8

Eliminate

Question 9

True or false; proton pump inhibitors have an antibacterial effect on H-pylori infections

Answer 9

True

Question 10

True or false; proton pump inhibitors have inflammatory effects and increase gastric irritation

Answer 10

False; they have ANTI-inflammatory effects and DECREASE gastric irritation

Question 11

Which is more effective in healing peptic ulcers and GERD; Histamine receptor blockers or proton pump inhibitors?

Answer 11

Proton pump inhibitors