1 Arthritis Flashcards
What are the goals of treating RA?
To decrease joint inflammation
To arrest the progression of the disease
What are the 3 general categories of RA drugs?
- Nonsteroidal anti inflammatory
- Glucocorticoids
• Disease –modifying antirheumatic drugs (DMARDs)
*wait to give steroids until later
Which drug is the first line of defense in treating RA?
Aspirin
Why is aspirin a great drug to treat RA?
It inhibits the synthesis of prostaglandins
Which increase pain and inflammation
What are the side effects of Aspirin as an RA treatment?
– Stomach irritation
***stops good prostaglandins
– Bleeding problems
***thromboxanes
– Impaired renal function
***stops good prostaglandins
– Diarrhea
***stops good prostaglandins
– Heart burn
***stops good prostaglandins
– Upper Respiratory Tract infection
*** leukotrines
What is the mechanism of action for glucocorticoids?
Binds to receptors in the cytoplasm of certain cells – forming a glucocorticoid-
receptor complex. Complex then moves to the cells nucleus, binds with certain cells and regulates inflammatory process
What are the side effects of glucocorticoids?
MOON FACE and
- Osteoporosis
- Bone loss
- Muscle wasting and weakness
- Hypertension
- Aggravation of DM
- Glaucoma
- Cataracts
Side effects of methotrexate
- Toxic drug
- Loss of appetite
- Nausea
- Intragastrointestinal hemorrhage
- Pulmonary problems
- Hemologic disorders
- Liver dysfunction
- Hair loss
Which works faster on arthritis; methotrexate or gold?
Methotrexate
What’s the most common form of joint disorder?
OA
What are the most common types of drugs to treat OA?
- Acetaminophen
- NSAIDs
- Disease modifying osteoarthritic drugs (DMOADs)
What is the drug of choice for OA pain?
Acetaminophen first drug of choice for OA for pain
What do NSAIDs do to treat OA? Do they have any adverse effects?
NSAIDs work on pain and
inflammation, Cause GI upset
COX __, is an NSAID which decreases GI upset to treat synovitis
COX 2 newer NSAID which decreases GI upset to treat synovitis
