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Virology > 19: picorna, calci > Flashcards

19: picorna, calci Flashcards

1
Q

Picornaviridae:

- genera

A

47 genera. most important:

Entero-, Tescho-, Hepato-, Avihepato-, Tremo-, Cardio-, Aphtho-, Erbo-, Parecho-, Kobuvirus

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2
Q

Picornaviridae:

  • Morphology
  • Biological properties
  • Antigenic properties
  • Diagnosis
A 
Morphology:
- +ssRNA genome
- ~25nm icosahedral capsid
- non enveloped
Resistance: generally good
- Entero-, Hepato-, Tescho-: 56°C, pH 3
- Cardio-, Rhinovirus: weaker

Biological properties:

  • Baltimore IV.: genome ~ mRNA – short replication cycle
  • single polyprotein processed by viral enzymes
  • generally stenoxen (except Aphtho) – in vitro too
  • CPE: rounding, rhexis

Antigenic properties:

  • good antigens
  • serotypes – no cross protection
  • transcapsidation

Diagnosis:

  • isolation
  • IF, CF (FMD)
  • indirect: VN, CF, AGID, ELISA
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3
Q

Enterovirus genus:

A

(Picornaviridae)

  • Swine vesicular disease (SVD, porcine picornavirus 9)
  • -> swine – clinical signs ~ FMD
  • -> antigenic structure ~ coxsackie B5
  • Bovine enterovirus (1-2)
  • Human poliovirus (1-3): polioencephalomyelitis
  • Human coxsackie virus A (1-24) and B (1-6)
  • -> aseptic meningitis; hand, foot, and mouth disease
  • Human echovirus (1-33) – enteric cytopathic human orphan
  • Rhinoviruses (rhinos – nose)
  • -> Common cold – cattle (1-3), human (~100)
  • -> thermosensitive mutants - rhinitis
  • Simian enteroviruses
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4
Q

Teschovirus genus:

A

(Picornaviridae)
- Porcine teschovirus 1: Teschen/Talfan disease
poliomyelitis, paralysis
Porcine teschovirus 2-8, 10-13: apathogen

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5
Q

Hepatovirus genus:

A

(Picornaviridae)

  • Hepatitis A
  • -> human – hepatitis, icterus
  • Simian hepatitis A
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6
Q

Tremovirus genus:

A

(Picornaviridae)

- Avian encephalomyelitis – chicken, Epidemic tremor

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7
Q

Cardiovirus genus:

A

(Picornaviridae)

  • Encephalomyocarditis virus
  • -> euryxen
  • -> reservoir: rodents
  • -> swine, horse, human, elephants
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8
Q

Aphthovirus genus:

A

(Picornaviridae)

  • Foot and mouth disease
  • -> serotypes: O, A, C, SAT-1, SAT-2, SAT-3, Asia-1
  • -> euryxen: ruminants, swine, (human)
  • -> vesicles (oral cavity, hoofs, enteric mucosa), myocarditis
  • Equine rhinitis A
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9
Q

Erbovirus genus:

A

(Picornaviridae)

- Equine rhinitis B

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10
Q

Parechovirus genus:

A

(Picornaviridae)

- Human, rodent parechoviruses – enteritis or apathogen

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11
Q

Kobuvirus genus:

A

(Picornaviridae)

- Aichi virus – human enteric disease

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12
Q

Avihepatovirus genus:

A

(Picornaviridae)

- Duck hepatitis A or 1

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13
Q

Unassigned picornaviruses:

A
  • Equine picornaviruses
  • Turkey hepatitis
  • Guineafowl enteritis
  • Avian entero-like viruses
  • Sea-animal enteroviruses
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14
Q

Picornavirales:

- family

A
  • Dicistroviridae
  • Iflaviridae
  • Caliciviridae
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15
Q

Picornavirales:

- morphology

A

Viruses with similar morphology
- 20-40 nm, icosahedral capsid, no envelop
- +ssRNA
Differences in genome organization, host spectrum

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16
Q

Dicistroviridae:

- subfamily

A

(Picornavirales)

  • Aparavirus
  • -> Acute bee paralysis virus
  • -> Israeli acute paralysis virus
  • -> Kashmir bee virus
  • Cripavirus
  • -> Black queen cell virus
17
Q

Iflaviridae:

- subfamiliy

A

(Picornavirales)

  • Iflavirus
  • -> Sacbrood virus
  • -> Deformed wing virus
18
Q

Caliciviridae:

- genera

A

(Picornavirales)

Vesi-, Lago-, Noro-, Sapovirus genus

19
Q

Caliciviridae:

  • Morphology
  • Biological properties
  • Antigenic properties
  • Diagnosis
A 
Morphology:
- +ssRNA genome
- ~40nm icosahedral capsid
- non enveloped
Resistance: good (56°C, pH 5)

Biological properties:
- Baltimore IV. – subgenomic mRNAs
- stenoxen - propagation in species specific tissue cultures
→ RHD: in vitro not possible to propagate
- CPE: lysis

Antigenic properties: good antigens

Diagnosis:

  • clinical signs
  • isolation if possible
  • AGID, IF, EM
  • serology: AGID, IIF
20
Q

Vesivirus genus:

A

(Picornavirales, Caliciviridae)

  • Vesicular exanthema of swine virus (VESV)
  • -> clinical signs ~ FMD
  • -> only swine, North America
  • San Miguel sea lion virus (~VESV)
  • Feline calicivirus
  • -> respiratory disease, mucosal erosions
  • Bovine-, cetacean-, primate-, reptile-, skunk caliciviruses
21
Q

Lagovirus genus:

A

(Picornavirales, Caliciviridae)

  • Rabbit hemorrhagic disease (RHD)
  • European brown hare disease (EBHD)
22
Q

Norovirus genus:

A

(Picornavirales, Caliciviridae)
- Norwalk, Hawaii, Mexico, Southampton viruses
→ human food-borne gastroenteritis

23
Q

Sapovirus genus:

A

(Picornavirales, Caliciviridae)
- Sapporo, Huston, London, Manchester, Parkville viruses
→ human food-borne gastroenteritis

24
Q

Unassigned caliciviruses:

A

Bovine-, canine-, porcine-, fowl-, mink caliciviruses

Virology (25 decks)

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