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Virology > 17a+b: asfar-hepadna, parvo, circo > Flashcards

17a+b: asfar-hepadna, parvo, circo Flashcards

1
Q

Asfaraviridae

- genus

A

(African swine fever)

- Asfivirus genus

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2
Q

Asfarviridae

  • Morphology
  • Biological properties
  • Antigenic properties
  • diagnosis
A

Morphology:

  • linear dsDNA
  • ~250nm icosahedral capsid
  • enveloped

Resistance: strong
- In raw pork meat the virus survives for months!

Biological properties:

  • Baltimore I. ↔ multiplication in the cytoplasm (viral enzymes)
  • multiplication in lymphatic cells – buffy coat culture
  • haemadsorption
  • stenoxen
  • reservoir (Africa): wart-hog
  • transmission: contact, arbo (ticks!)

Antigenic properties:

  • hidden protective antigen – neutralizing antibodies emerge in late stage of infection!
  • no vaccines available
  • persisting infections
  • immunocomplex deposition – clinical signs

Diagnosis:

  • clinical signs = classical swine fever – swine experiment
  • isolation – buffy coat
  • IF, ELISA
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3
Q

Asfivirus genus:

A 
(Asfarviridae)
African swine fever
- swine – high morbidity and mortality
- acute: fever, haemorrhage (skin, organs)
- chronic: paralysis, wasting
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4
Q

Hepadnaviridae:

- genera

A
  • Orthohepadna-, Avihepadnavirus genus
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5
Q

Hepadnaviridae:

  • Morphology
  • Biological properties
  • Antigenic properties
  • diagnosis
A 
Morphology:
- circular ss/dsDNA
- ~ 45 nm icosahedral capsid
- enveloped
Resistance: weak (low pH, detergents)

Biological properties:

  • Baltimore VI! – replication with reverse transcriptase
  • stenoxen viruses
  • transmission: blood, sexual route, close contact
  • chronic, persisting infections

Antigenic properties:
- HBsAg - protective, HBcAg, HBeAg

Diagnosis:
- ELISA direct and indirect

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6
Q

Orthohepadnavirus genus:

A

(Hepadnaviridae)

  • Human hepatitis B
  • -> serumhepatitis
  • -> hepatocarcinoma
  • woodchuck hepatitis
  • ground squirrel hepatitis
  • bat hepatitis
  • monkey hepatitis
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7
Q

Avihepadnavirus genus:

A

(Hepadnaviridae)

  • Duck hepatitis (B)
  • -> Far East
  • -> hepatitis
  • heron, parrot hepatitis B viruses
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8
Q

Parvoviridae:

- Subfamilies, genera:

A
  • Parvovirinae: Proto-, Avi-, Amdo-, Boca-, Copi-, Tetra-, Erythro-, Dependoparvovirus genus
  • Densovirinae
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9
Q

Parvoviridae:

  • Morphology
  • Biological properties
  • Antigenic properties
  • diagnosis
A

Morphology:
- linear ssDNA – self-priming, hairpin ends
- ~20nm icosahedral capsid
- non enveloped
Resistance: very strong (60°C, 60 min; pH 3-9)

Biological properties:

  • Baltimore II.
  • -> cellular polymerase - multiplication in dividing cells
  • -> complementation – adeno- or herpesvirus infected cells
  • hemagglutination
  • stenoxen

Antigenic properties:
- very good antigens – long immunity
- cross reactions – cross immunity
→ related viruses (mutants) – panleukopenia, mink enteritis, canine parvovirus 2

Diagnosis:

  • isolation in dividing cells – intranuclear inclusion bodies
  • HA, IF, AGID
  • Serology: HAI, VN
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10
Q

Protoparvovirus genus:

A

(Parvoviridae, Parvovirinae)
- Porcine parvovirus – SMEDI
→ Stillbirth, Mummification, Embryonic Death, Infertility
- Canine parvovirus 2 – enteritis, myocarditis, exsiccosis
- Feline panleukopenia virus – panleukopenia
- Mink enteritis virus

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11
Q

Aviparvovirus genus:

A

(Parvoviridae, Parvovirinae)

- Chicken parvovirus – stunting, diarrhoea, mortality

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12
Q

Amdoparvovirus genus:

A

(Parvoviridae, Parvovirinae)

  • Aleutian mink disease virus
  • -> immunocomplex disease – hemorrhage, nephritis
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13
Q

Bocaparvovirus genus:

A

(Parvoviridae, Parvovirinae)

  • Bovine parvovirus
  • Canine minute virus (CPV-1)
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14
Q

Erythroparvovirus genus:

A

(Parvoviridae, Parvovirinae)
- B 19 virus
human transient aplastic crisis, fetal wastage (hydrops)
- Simian erythroviruses

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15
Q

Dependoparvovirus genus:

A 
(Parvoviridae, Parvovirinae)
- Adeno associated viruses (human, canine, bovine, ect.)
- Goose parvovirus – Derzsy’s disease
ascites, respiratory disease, enteritis
- Muscovy duck parvovirus
- Snake parvovirus
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16
Q

Copi-, Tetraparvovirus genus:

A

(Parvoviridae, Parvovirinae)

- ungulate parvoviruses

17
Q

Densovirinae:

A

(Parvoviridae)
(densonucleosis virus)
- arthropod pathogens

18
Q

Circoviridae:

- Genera

A

Circo-, Cyclovirus genus

19
Q

Circoviridae:

  • Morphology
  • Biological properties
  • Antigenic properties
  • diagnosis
A 
Morphology:
- circular ssDNA
- ~20nm icosahedral capsid
- non enveloped
Resistance: very strong (60°C, 60 min; pH 3-9)

Biological properties:
- Baltimore II.
–> cellular polymerase - multiplication in dividing cells
→ bone marrow cells, leukocytes - immunosuppressant
- germinative infections
- stenoxen

Antigenic properties: good antigens ↔ immunosuppression

Diagnosis:

  • isolation: dividing cells, embryo
  • IF (leukocytes)
  • Serology: ELISA
20
Q

Circovirus genus:

A

(Circoviridae)

  • Porcine circovirus – PCV-1; PCV-2: PMWS, PDNS
  • -> wasting, hemorrhage, immunosuppression
  • Beak and feather disease virus
  • -> parrots
  • -> beak and feather deformities, immunosuppression
  • Goose circovirus
  • -> immunosuppression
  • Canary, pigeon, mallard duck, Muscovy duck circoviruses
21
Q

PCV-2:

A

(Circoviridae, Circovirus genus: Porcine circovirus)

  • Post-weaning Multisystemic Wasting Syndrome (PMWS)
  • Porcine Dermatitis and Nephropathy Syndrome (PDNS)
  • -> wasting, hemorrhage, immunosuppression
22
Q

Anelloviridae:

- genera

A

Gyrovirus, Alpha-Zetatorquevirus

23
Q

Anelloviridae:

  • Morphology
  • Biological properties
  • Antigenic properties
  • diagnosis
A 
Morphology:
- circular ssDNA
- ~20nm icosahedral capsid
- non enveloped
Resistance: very strong (60°C, 60 min; pH 3-9)

Biological properties:
- Baltimore II.
–> cellular polymerase - multiplication in dividing cells
→ bone marrow cells, leukocytes - immunosuppressant
- germinative infections
- stenoxen

Antigenic properties: good antigens ↔ immunosuppression

Diagnosis:

  • isolation: dividing cells, embryo
  • IF (leukocytes)
  • Serology: ELISA
  • PCR
24
Q

Gyrovirus genus:

A

(Anelloviridae)

  • Chicken infectious anemia
  • -> anemia, immunosuppression
25
Q

Alpha-Zetatorquevirus genus:

A

(Anelloviridae)
Torque teno virus
- human, swine, horse, dog, cat, seal…
- asymptomatic infection (associated to other diseases)
- 100% seropositivity, life long viraemia

Virology (25 decks)

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