16: pox Flashcards
Poxviridae:
- Subfamilies, genera
- Chordopoxvirinae: Orthopox-, Parapox-, Avipox-, Capripox-, Leporipox-, Suipox-, Cervidpox-, Yatapox-, Molluscipoxvirus genus
- Entomopoxvirinae: insect poxviruses (A, B, C)
Poxviridae:
- morphology
- biological properties
- antigentic properties
- diagnosis
Morphology:
- linear dsDNA
- ~200×400nm complex capsid with lipids
- Morphology variants!! See notes
Resistance: usually good (scabs)
- Chloroform inactivates all, ether only capri-, para- and leporipoxviruses
Biological properties:
- Baltimore I. ↔ multiplication in the cytoplasm (viral enzymes)
- embryonated eggs – CAM inoculation
- mainly stenoxen
- recombinations within genera
- Orthopox, Parapox – zoonoses
- infection: air borne, contact, arbo
- papule (cell proliferation) → pustule → scab → scar
Antigenic properties:
- strong antigens (except Parapox) – long immunity
- cross neutralizations within genera
- -> variola – vaccinia
- Orthopox: haemagglutinin
Diagnosis:
- clinical signs
- isolation: embryonated egg – CAM
Chordopoxvirinae:
- genus
- Orthopoxvirus genus:
- Parapoxvirus genus:
- Avipoxvirus genus:
- Capripoxvirus genus:
- Leporipoxvirus genus:
- Suipoxvirus genus:
- Yatapoxvirus genus:
- Molluscipoxvirus genus:
Orthopoxvirus genus:
(Poxviridae, chordopoxvirinae)
- Cowpox (cattle skin, teats)
rodents → cat → human
- Buffalopox (buffalo skin)
- Camelpox (camel skin, eye, pneumonia)
- Ectromelia (mice, skin – loose of legs, generalized)
- Variola (smallpox: human - skin, pneumonia)
- Vaccinia (mutant cowpox – vaccine against Variola)
- Monkeypox (monkey, rodent, human)
Parapoxvirus genus:
(Poxviridae, chordopoxvirinae)
- Pseudocowpox
- -> cow: teat scabs
- -> humans: milker’s nodule
- Bovine papular stomatitis
- -> calf: oral scabs
- Contagious ecthyma, orf
- -> lamb: mouth, lips - scabs
- -> humans: skin, lips, eyes
- Squirrel parapoxvirus – skin lesions (head, lips, eyes)
- Sealpox
Avipoxvirus genus:
(Poxviridae, chordopoxvirinae)
- Fowlpox
- Canarypox
- Pigeonpox
- Psittacinepox
- Turkeypox
Capripoxvirus genus:
(Poxviridae, chordopoxvirinae)
- Sheep pox
- -> skin – wool loss, pneumonia, generalized
- Goat pox
- Lumpy skin disease
- -> cattle, wild ruminants
Leporipoxvirus genus:
(Poxviridae, chordopoxvirinae)
- Myxomatosis
- -> rabbit (Oryctolagus)– myxomas, pneumonia
- -> transmission: mosquitoes
- Hare-fibroma virus
- -> hare (Lepus) - tumors
- Shope-fibroma virus
- -> American cotton-tailed rabbit (Sylvilagus) - tumors
Suipoxvirus genus:
(Poxviridae, chordopoxvirinae)
- Swinepox
- -> skin papulas
- -> transmission: lice
Yatapoxvirus genus:
(Poxviridae, chordopoxvirinae)
- Yabapox: monkey tumors
- Tanapox: human skin lesions
Molluscipoxvirus genus:
(Poxviridae, chordopoxvirinae)
Molluscum contagiosum virus: human skin lesions
