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Virology > 15: herpes > Flashcards

15: herpes Flashcards

1
Q

Herpesvirales

A

Allo-, Malaco-, Herpesviridae

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2
Q

Herpesviridae:

- subfamilies, genera

A
  • Alphaherpesvirinae: Simplex-, Varicello-, Mardi-, Iltovirus
  • Betaherpesvirinae: Cytomegalo-, Muromegalo-, Probosci-, Roseolovirus
  • Gammaherpesvirinae: Lymphocrypto-, Rhadino-, Maca-, Percavirus
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3
Q

Herpesviridae:

  • Morphology
  • biological properties
  • antigenic properties
  • diagnosis
A 
Morphology:
- linear dsDNA
- ~100 nm icosahedral capsid
- enveloped – 150-200 nm
Resistance:  weak (detergents, heat)

Biological properties:

  • latent infections – episoma, integration
  • strong CPE
  • intranuclear inclusion bodies
  • syncytia
  • cell rounding, lysis
  • oncogenity – mainly gammaherpesviruses
  • generally stenoxen (a few exceptions)

Antigenic properties:

  • weak immunogenes
  • cross reactions within genera
  • Aujeszky’s disease – IBR
  • EHV-1 – EHV-4
  • Marek’s disease – turkey herpes

Diagnosis:

  • isolation – cocultivation!
  • NA-hybridization, PCR
  • VN for identification
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4
Q

Alphaherpesvirinae:

- Genus

A
  • Simplex-, Varicello-,

Mardi-, Iltovirus

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5
Q

Simplexvirus genus:

A

(herpesviridae, Alphaherpesvirinae)

  • Bovine herpesmamillitis (BoHV-2)
  • Simian herpes (B-virus)
  • Human herpes simplex (HHV 1-2)
  • -> labial and genital herpes – keratitis, encephalitis!
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6
Q

Varicellovirus genus:

A

(herpesviridae, Alphaherpesvirinae)

  • Infectious bovine rhinotracheitis (IBR, BoHV-1, BoHV-5)
  • -> rhinotracheitis, abortion
  • -> Infectious pustular vulvovaginitis (IPV), balanopostitis (IBP)
  • Equine abortion/rhinopneumonitis (EHV-1, EHV-4, EHV-6)
  • Coital exanthema (EHV-3)
  • Pseudorabies – Aujeszky’s disease (SuHV-1)
  • -> swine: abortion, respiratory and CNS signs
  • -> other species: lethal CNS disease ~ rabies
  • Canine herpesvirus (CHV-1)
  • -> nasal and genital mucosa – puppy generalized
  • Feline rhinotracheitis (FeHV-1)
  • Deer, reindeer, buffalo, monkey, seal herpesviruses
  • Human Varicella - Zoster (HHV-3)
  • -> Chickenpox - Shingles
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7
Q

Mardivirus genus:

A

(herpesviridae, Alphaherpesvirinae)

  • Marek’s disease virus (GaHV 2-3)
  • -> CNS signs, paralysis
  • -> lymphatic tumors
  • Turkey herpesvirus (MeHV-1)
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8
Q

Iltovirus genus:

A

(herpesviridae, Alphaherpesvirinae)

- Infectious laryngotracheitis (GaHV-1)

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9
Q

Betaherpesvirinae:

- genus

A
  • Cytomegalovirus genus:
  • Muromegalovirus genus:
  • Proboscivirus genus:
  • Roseolovirus genus:
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10
Q

Cytomegalovirus genus:

A

(Herpesviridae, Betaherpesvirinae)

  • Human cytomegalovirus
  • Monkey cytomegaloviruses
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11
Q

Muromegalovirus genus:

A

(Herpesviridae, Betaherpesvirinae)

- Mouse, rat cytomegaloviruses

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12
Q

Proboscivirus genus:

A

(Herpesviridae, Betaherpesvirinae)

- Elephant cytomegalovirus

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13
Q

Roseolovirus genus:

A

(Herpesviridae, Betaherpesvirinae)

- Human: Roseola infectiosa (HHV 6, 7)

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14
Q

Gammaherpesvirinae:

- Genus

A
  • Lymphocryptovirus genus
  • Macavirus genus
  • Pecavirus genus
  • Rhadinovirus genus
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15
Q

Lymphocryptovirus genus:

A

(Herpesviridae, gammaherpesvirinae)

  • Epstein-Barr virus (HHV-4)
    • > Mononucleosis infectiosa
  • -> Burkitt’s lymphoma
  • -> Nasopharyngeal carcinoma
  • Baboon, monkey, ape herpesviruses
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16
Q

Macavirus genus:

A

(Herpesviridae, gammaherpesvirinae)

  • Malignant catarrhal fever of cattle (AlHV-1, OvHV-2)
  • -> wildebeest, sheep – asymptomatic carrier
  • -> cattle – oedema, erosions, pneumonia
17
Q

Pecavirus genus:

A

(Herpesviridae, gammaherpesvirinae)

  • Equid herpesvirus 2 – foal pneumonia + Rh. equi
  • Equid herpesvirus 5 – pulmonary fibrosis
18
Q

Rhadinovirus genus:

A

(Herpesviridae, gammaherpesvirinae)

  • Bovine herpesvirus 4 (Movar) – pneumonia
  • Kaposi’s sarcoma-associated herpesvirus (HHV-8)
  • -> human, in immunosuppressant patients
  • rodent, ruminant herpesviruses
19
Q

Unassigned herpesviruses:

A
  • Swine inclusion body rhinitis (SuHV-2)

- Duck plague (AnHV-1) (recently classified as Mardivirus)

20
Q

Fish herpesviruses:

A

Alloherpesviridae

  • Koi herpes – carp
  • Sturgeon, salmon herpesviruses

Virology (25 decks)

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