19. acute and chronic pancreatitis, EPI

Question 1

pancreatitis etiology

Answer 1

damage of pancreas - hypoxia, acidosis, oxidative stress
lysosomal dysfunction: pathologic activation of trypsin, - damage of organelles- inflammation (vicious circle)

damage of adjacent organs: cholestasis, EHBO
damage of distant organs: SIRS ->MODS

Question 2

pancreatitis diagnosis

Answer 2

GOLD: PLI - pancreatic lipase immunoreactivity

history, clinical signs, diet
US: decreased echogenicity of pancreas

Question 3

pancreatitis symptoms:

Answer 3

vomit, pain, anorexia, lethargy, diarrhea

dehydration

Question 4

pancreatitis treatment

Answer 4

1. fluid therapy
2. analgesics: opioid
   3: antiemetic: maropitant
   4: complications: omeprazole, AB,

Diet: low fat, high digestible

Question 5

chronic pancreatitis

Answer 5

idiopathic or autoimmune
months - years
postprandial pain
recurrent acute episodes

Question 6

feline pancreatitis

Answer 6

usually with a concurrent disorder (IBD, cholangitis)

bacterial translocation and hematogenous spread -> inflammation

Question 7

EPI etiology

Answer 7

exocrine pancreatic insufficiency
pancreatic acing atrophy, continuous loss of acing cells
causes: autoimmune, chronic pancreatitis

Question 8

EPI signs

Answer 8

alert, responsive but skinny
polyphagia, weight loss, cachexia
diarrhea: pale clay like, undigested particles

Question 9

EPI diagnosis

Answer 9

GOLD: TLI- trypsin like immunoreactivity

Question 10

EPI treatment

Answer 10

life long pancreatic enzymes
diet: highly digestible, low fat, NO FIBRE
cobalamin supplementation
AB if ARE develops