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OMF Pathology > 17 Oral Manifestations of Systemic Diseases > Flashcards

17 Oral Manifestations of Systemic Diseases Flashcards

1
Q

When xcess bilirubin in the bloodstream accumulates resulting in yellowish discoloration of the skin and mucosa, what is it called?

A

Jaundice

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2
Q

What is this oral manifestation called?

A

Jaundice

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3
Q

What fiber has a higher affinity for bilirubin?

A

Elastin fibers

(more elastin found in sclera, lingual frenum, and soft palate)

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4
Q

Your pt has a markedly yellow lingual frenum. What four things can manifest with such yellow discolorations?

A

Anemia, cancer, hepatic infection, and Gilbert Syndrome

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5
Q

What are six classifications of amyloidosis?

A
  1. Organ-limited
    * Systemic
    1. Primary
    2. Myeloma associated
    3. Secondary
    4. Hemodialysis associated
    5. Heredofamilial
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6
Q

Primary and myeloma-associated systemic amyloidosis affects what age group? And what are most common sites affected?

A
  • older adults
  • Mostly affected areas are eyelids, neck, and lips
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7
Q

Secondary systemic amyloidosis develops as a result of what?

A

chronic inflammatory process

(like TB, sarcoidosis, or osteomyelitis)

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8
Q

What happens with hemodialysis-associated amyloidosis?

A

All proteins aren’t filtered out of blood, so they accumulate in plasma and eventually in bones and joints

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9
Q

T or F: Heart conditions and renal failure are frequently seen in patients with heredofamilial amyloidosis.

A

True

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10
Q

Vitamin A (retinol) deficiency can cause what?

A

blindness

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11
Q

Vitamin B1 (thiamin) deficiency can cause what?

A

Beriberi

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12
Q

Vitamin B2 (riboflavin) deficiency can cause what?

A

angular cheilitis, glossitis

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13
Q

Vitamin B3 (niacin) deficiency can cause what?

A

Pellagra (dermatitis, dementia, diarrhea)

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14
Q

Vitamin C (ascorbic acid) deficiency can cause what?

A

scurvy

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15
Q

Vitamin D (considered a hormone) deficiency can cause what?

A

Rickets, osteomalacia

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16
Q

Vitamin K deficiency can cause what?

A

Coagulation problems because it’s needed for activation of Factors II, VII, IX, and X

17
Q

What is the most common cause of anemia in the U.S and the World?

A

Iron deficiency anemia

18
Q

What are the oral manifestations of iron deficiency anemia?

A

Angular cheilitis, and atrophic glossitis

19
Q

Plummer-Vinson Syndrome is characterized by what three manifestations?

A
  1. iron deficiency anemia
  2. glossitis
  3. dysphagia
20
Q

T or F: Plummer-Vinson Syndrome is considered a premalignant process.

A

True

21
Q

Most patients with Plummer-Vinson Syndrome are women of __________ or _______ ________ background between the ages of 30 & 50.

A

Scandinavian, Northern European

22
Q

What is unique about patients’ nails with Plummer-Vinson Syndrome?

A

Koilonychia (spoon-shaped nails)

23
Q

Pernicious anemia is caused by poor absorption of _________.

A

Cobalamin (vitamin B12, extrinsic factor)

24
Q

What oral manifestation does pernicious anemia present with?

A

Atrophic glossitis

25
Q

What hormone causes gigantism?

A

Growth hormone

26
Q

How does gigantism happen?

A

Increased production of growth hormone, usually related to a functioning pituitary adenoma. All before the epiphyseal plates close.

27
Q

If you couldn’t tell your patient had gigantism when they walk into your office at 8’ tall, what oral manifestation would they present with?

A

macrodontia

28
Q

How is acromegaly different from gigantism?

A

Acromegaly is marked by increased growth hormone after the closure of epiphyseal plates

29
Q

What characteristics would you see with acromegaly?

A

Prognathism with diastema formation, and macroglossia

30
Q

Hypothyroidism in infancy is called ______.

A

Cretinism

31
Q

Hypothyroidism in adulthood is called __________.

A

Myxedema

32
Q

Why do DM patients have a higher chance for periodontitis and experience delayed healing?

A

They have impaired neutrophil function, and abnormal vasoconstriction of small vessels causing lowered perfusion.

33
Q

What are some oral manifestations of Type I DM?

A
  • periodontitis
  • delayed healing
  • candidiasis
  • zygomycosis
  • xerostomia
  • enlarged, erythematous gingiva
  • sialadenosis
  • bilateral enlarged parotid glands
34
Q

Nodular swellings and a “Cobblestone appearance” of the oral mucosa are manifestations of what condition?

A

Crohn’s Disease

35
Q

Linear ulcerations can be a sign for what condition?

A

Crohn’s disease

36
Q

What is this tongue condition called?

A

glossitis

37
Q

This is an oral manifestation for what systemic diseases?

A
  • iron deficiency anemia
  • pernicious anemia
  • plummer-vinson syndrome
  • vitamin B2 (riboflavin) deficiency

OMF Pathology (21 decks)

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