15 Odontogenic Cysts & Tumors Flashcards
What is a dentigerous cyst?
A cyst that originates from the separation of the fillocle from around the crown of a developing, unerupted tooth.
Where does fluid accumulate in a dentigerous cyst?
Between the Reduced Enamel Epithelium and Crown of unerupted tooth
What is the most common developmental cyst?
Dentigerous cyst
What tooth is most commonly affected by a dentigerous cyst?
mandibular 3rd molars
How do dentigerous cysts appear on radiograph?
- unilocular radiolucency
- well-defined
- sclerotic border
This RL is fluid between the REE and crown of the unerupted tooth. What is your diagnosis?
Dentigerous cyst
Pathology is asymptomatic, has very slight cortical expansion, and the tooth is unerupted. What is your diagnosis?

Dentigerous cyst
What is your differential diagnosis for a unilocular RL around an unerupted, impacted tooth?

- Dentigerous cyst
- Odontogenic keratocyst
- Ameloblastoma
- Central cell granuloma
What is an eruption cyst?
A cyst that originates from the separation of the follicle from the crown of an erupting tooth.
What is the difference between a dentigerous cyst and eruption cyst?
A dentigerous cyst is in an unerupted tooth still in bone, and an eruption cyst is involving a tooth that has exited bone but not soft tissue.
What patient demographic will you typically see eruption cysts?
Patients younger than 10 years old
What is an eruption hematoma?
An eruption cyst that experienced trauma and has bleeding into the cystic fluid
Pt is young. What could these be?

Eruption cysts (or eruption hematomas)
What is this if radiograph shows the tooth only has soft tissue overlying the crown?

eruption cyst (or eruption hematoma)
What cells give rise to an odontogenic keratocyst?
Cell rests of the dental lamina
Odontogenic keratocysts tend to grow in what direction?
Anterior to posterior
Odontogenic keratocysts are associated with what syndrome?
Nevoid Basal Cell Carcinoma Syndrome
Odontogenic keratocysts have a ___% recurrence rate.
30%
If a patient age 20 or younger has an OKC, he or she should be further evaluated to rule out what syndrome?
Gorlin Syndrome (aka Nevoid Basal Cell Carcinoma Syndrome)
Growth in an anterior-posterior direction in a 20 yr old pt. What is this?

Odontogenic Keratocyst (aka OKC)
Upon surgery there was a “cheese-like” substance found inside the cavity. What is your diagnosis?

Keratocystic Odontogenic Tumor (aka odontogenic keratocyst)
Pt has rib abnormalities, multiple documented basal cell carcinomas, and this radiographic finding. What is your diagnosis of the finding, and their syndrome?

Radiographic finding: odontogenic keratocyst
Syndrome: Gorlin syndrome
What are four characteristics of Gorlin Syndrome?
- Multiple basal cell carcinomas
- Odontogenic keratocyst(s)
- Calcification of Falx Cerebri
- Splayed or Bifid ribs
This pathology is autosomal dominant and usually presents OKCs and basal cell carcinomas. What is it?
nevoid basal cell carcinoma syndrome
What kind of epithelium lines an odontogenic keratocyst?
Parakeratinized
What kind of epithelium lines an orthokeratinized odontogenic cyst?
orthokeratinized
Orthokeratinized odontogenic cysts appear like what on radioraph?
Dentigerous cyst - need biopsy to differentiate
Upon radiograph you think it might be a dentigerous cyst, but histology shows this. What is the diagnosis?

Orthokeratinized odontogenic cyst
What is the soft tissue counterpart of the lateral periodontal cyst?
Gingival Cyst of the Adult
Gingival cyst of the adult arises from what cells?
Rests of dental lamina
Where does gingival cyst of the adult usually present?
Mandibular canine/premolar area
What is this?

Gingival cyst of the adult
Why is this not a mucocele? What is it?

Not a mucocele because those can NOT occur on gingiva. It’s really a Gingival Cyst of the Adult
What is the intrabony counterpart of the gingival cyst of the adult?
lateral periodontal cyst
Where do lateral periodontal cysts usually present?
mandibular canine/premolar/lat. incisor area
Usually unilocular, what is lateral periodontal cyst called when multilocular?
Botryoid Odontogenic Cyst
What is this counterpart of gingival cyst of the adult?

lateral periodontal cyst
What is this?

lateral periodontal cyst
Diagnosis.

Lateral periodontal cyst
What is this? Teeth are vital.

lateral periodontal cyst
What is also called a Gorlin Cyst?
Calcifying Odontogenic Cyst
Compared to Gingival Cysts of the Adult, where do Calcifying Odontogenic Cysts mostly occur?
Incisor/canine area of either mx or md
What radiographic feature(s) do calcifying odontogenic cysts have?
- Unilocular
- RL
- 50% have RO specks within lesion
- 1/3 associated with unerupted tooth
What calcifies in Calcifying odontogenic cysts?
Ghost cells
What is this?

Calcifying odontogenic cyst
Diagnosis.

Calcifying odontogenic cyst
Tricky, but what could this be based on the RO specks associated with the unerupted tooth?

Calcifying odontogenic cyst
Glandular odontogenic cysts have a predilection for what area of mouth?
Anterior mandible
What is the most recently added pathology to the topic of developmental cysts (in 1988)?
glandular odontogenic cyst
If these radiographic findings are associated with a salivary gland malformation, what could this be?

glandular odontogenic cyst
Which pathology characteristically develops on the buccal bifurcation aspect of the mandibular first permanent molar?
Buccal Bifurcation Cyst
What demographic do buccal bifurcation cysts appear?
children, usually around 10 yrs
What are radiographic findings of Buccal Bifurcation Cysts?
- roots are tipped lingually
- unilocular RL on buccal side of tooth
What is this?

buccal bifurcation cyst
What is this?

buccal bifurcation cyst
What is the most common clinically significant odontogenic tumor?
Ameloblastoma
What are the three types of ameloblastomas?
- Conventional solid or multicystic (85%)
- Unicystic (14%)
- Peripheral (soft tissue)
A large ameloblastoma loculation is described as what?
soap bubbles
Smaller ameloblastoma loculations are described as?
Honeycombed
What are the two most common patterns of ameloblastomas?
Follicular and Plexiform
Desmoplastic ameloblastomas have a predilection for what area of the mouth?
Anterior maxilla
Ameloblastoma shares what histologic similarities with odontogenic keratocyst?
- palisading, hyperchromatic basal layer
What is this “soap bubble” finding?

ameloblastoma
What is this? Histology shows reversed palisading, hyperchromatic basal layer.

ameloblastoma
Not as common, but what could you put on your differential for “bump on the gums” (3 Ps and F)?
Peripheral ameloblastoma
Painless, non-ulcerative, sessile lesion on retromolar pad. What could this be?

peripheral ameloblastoma
This is not one of the 3 P’s or a fibroma, and basal layer is reversed. What is this?

peripheral ameloblastoma
This pathology is usually circumscribed, unilocular, and involving the crown of an unerupted canine.
Adenomatoid odontogenic tumor (AOT)
Where does the RL extend to, in adenomatoid odontogenic tumors?
Beyond the CEJ of the tooth - unlike dentigerous cysts which are higher on the tooth
Tumor has a thick, fibrous capsule upon enucleation. What is this?

Adenomatoid odontogenic tumor