(16) Clotting Cascade (Staudinger)

Question 1

Answer 1

D. Time required for full expression of the Factor II, VII, IX and X genes

Question 2

What are the Vitamin K dependent factors?

Answer 2

Factor X (LONG HALF LIFE 40-60 h)

Factor IX

Factor II (LONG HALF LIFE 60 h)

Factor VII

Protein C

Protein S

Question 3

What is the extrinisc pathway activated by?

Answer 3

External trauma

(blood to escape from the vascular system)

Question 4

What is the intrinsic pathway activated by?

Answer 4

Trauma inside the vascular system

(* activated by platelets, exposed endothelium, chemicals, or collagen)

Question 5

What factors does the common pathway include?

Answer 5

I

II

V

X

Question 6

What is primary hemostasis?

Answer 6

Platelets in the blood aggregate at the injury site and form a platelet plug to block the hole

Question 7

What is secondary hemostasis?

Answer 7

Platelet plug is further reinforced by a fibrin mesh produced through proteolytic coagulation cascase

Question 8

What is the key difference b/w primary and secondary hemostasis?

Answer 8

Primary hemostasis makes a weak platelet plug at the injury site,

While secondary hemostasis makes it strong by generating a fibrin mesh on it

Question 9

Vitamin K is a cofactor in synthesizing factors…

Answer 9

II

VII

IX

X

Protein s

Protein c

Question 10

Warfarin (coumadin) works by…

Answer 10

Decreasing the activity of vitamin k-dependent epoxide reductase;

lengthening the time it takes for a clot to form

Question 11

Which form of warfarin is more active?

S-warfarin or R-warfarin?

Answer 11

S-warfarin!!!

“So Strong”

Question 12

What do protein c and protein s do?

Answer 12

Maintains the permeability of blood vessles

*Proteolytically inactivate Factor 5a and Factor 8a

Question 13

Hemophilia A, aka?

Answer 13

Factor VIII deficiency

or

Classic Hemophilia A

*unable to activate factor X

Question 14

Answer 14

B. Facilitation of the conversion of plasminogen to plasmin

Question 15

Answer 15

C. VII

PT is typically 12-13 seconds

PTT is typically 30-50 seconds

Question 16

Mneumonics for prothrombin (PT) and partial thromboplastin time (PTT)?

Answer 16

Extrinsic pathway: PET –> PT measures the extrinsic pathway

Intrinsic pathway: PITT –> PTT measures intrinsic pathway

Question 17

Which vitamin K dependent factor has the shortest half life?

Answer 17

Factor VII

4-6 hours

Question 18

Which vitamin K dependent factor has the longest half life?

Answer 18

Factor II

&

Factor X

60 h

Question 19

Answer 19

D. Factor S

Question 20

Answer 20

F. Warfarin