15 - Diabetes Flashcards

1
Q

List examples of natural health products

A
  • Vitamins and Minerals
  • Herbal Remedies
  • Homeopathic medicines
  • Traditional medicines such as TCM
  • Probiotics, amino acids and essential fatty aids
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2
Q

What are herbal remedies?

A

Substances derived from plants used for medicinal properties

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3
Q

What are the pharmacists’ responsibilities with NHPs

A
  • Safety first !!
  • Assessment
  • Education - Practical tips
  • Support - Empowerment
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4
Q

What are concerns that ppl have with NHPs

A
  • Side effects
  • Drug Interactions
  • Impurities
  • Many different names for products
  • May copy, increase or oppose the effects of drugs
  • Many unanswered questions regarding safety, efficacy, dosing, drug interactions
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5
Q

What is the active component in french lilac/goat’s rue?

A

A guanidine

**Where metformin came from - type of biguanide

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6
Q

Is French Lilac/Goat’s Rue recommended ?

A

too toxic for regular treatment - DO NOT USE

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7
Q

Possible actions of Alpha-lipoic Acid-Thioctic Acid ?

A

improves insulin sensitivity and glucose disposal

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8
Q

SE of Alpha-lipoic Acid-Thioctic Acid ?

A

nausea, dizziness and skin rash

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9
Q

Interactions with Alpha-lipoic Acid-Thioctic Acid ?

A
  • diabetes meds
  • chemotherapy
  • thyroid disease
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10
Q

Alpha-lipoic Acid-Thioctic Acid:

Possibly safe when ?

A

when used orally appropriately from 4 months - 4 years (NOT SAFE OVER 4 YEARS)

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11
Q

Alpha-lipoic Acid-Thioctic Acid:

Effective?

A

possibly effective for diabetes

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12
Q

What is the active component of Glucomannan ?

A

non absorbed polysaccharide

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13
Q

MOA of Glucomannan

A

delays glucose absorption

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14
Q

SE of Glucomannan

A

Laxitive effect, esophageal and gastrointestinal obstructions reported with tablet form

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15
Q

Is Glucomannan safe?

A

safe when used as food or in powder or capsule form for up to 4 months

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16
Q

Is Glucomannan effective?

A

possibly effective

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17
Q

Drug interactions with Glucomannan?

A

decreases absorption of other meds and fat soluble vitamins

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18
Q

What is Chromium ?

A

Essential trace element required for normal glucose metabolism

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19
Q

Action of Chromium?

A

Reduce Fasting Blood Glucose, Insulin and A1C

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20
Q

Side effects of Chromium ?

A

Well tolerated, headache, insomnia, sleep disturbances, irritability and mood changes

21
Q

Safety of Chromium ?

A

likely safe orally when used short term. has been safely used in doses up to 1000 mcg/day up to 6 months

22
Q

Is Chromium effective ?

A

Possibly effective 40-80% of patients have improved glucose tolerance
*Thought to be effective only in deficiency

23
Q

Active components of bitter melon ?

A
  • charantin
  • polypeptide P
  • vicine
24
Q

Possible actions of bitter melon

A
  • increased insulin secretion
  • tissue glucose uptake
  • decreased gluconeogenesis
25
Q

SE of bitter melon

A
  • diarrhea
  • GI upset and pain
  • two cases of hypoglycaemic coma in children drinking tea
26
Q

Safety of bitter melon ?

A

possibly safe when used orally up to 3 months

27
Q

Is bitter melon effective?

A

insufficient reliable evidence to rate

28
Q

_____ _____ is an insulin like protein, common in India

A

bitter melon

29
Q

Possible actions of Fenugreek ?

A

seeds contain 50% fibre and pectin delays gastric emptying, slowing glucose absorption, increase insulin secretion

30
Q

SE of Fenugreek

A

flatulence, diarrhea, hypersensitivity reactions

31
Q

Avoid Fenugreek in those with _____ allergy

A

peanut

32
Q

Is Fenugreek safe in pregnancy ?

A

NO - Unsafe

33
Q

_____ is a reasonable time frame to do A1C

A

3 months

34
Q

Active component of Ginseng

A

Ginsenosides

35
Q

Possible actions of Ginseng ?

A

increases glucose transport and uptake, modulates insulin secretion

36
Q

SE of Ginseng?

A

nervousness, excitation, headache, hypertension, insomnia

37
Q

Interactions with Ginseng?

A

May interfere with anticoagulation

38
Q

Safety considerations with Ginseng?

A

Concern with adulteration (failure to meet standards). Use for short term only up to 12 weeks

39
Q

Efficacy of Ginseng ?

A

possibly effective, evidence limited

40
Q

Active component of Cassia cinnamon?

A

polyphenolic polymers

41
Q

Possible action of Cassia cinnamon ?

A

enhance insulin action, increases glucose uptake

42
Q

SE of Cassia cinnamon ?

A

well tolerated

43
Q

High amounts of Cassia cinnamon can cause ?

A

hepatotoxicity

44
Q

What do you do if a patients wants to use a herbal therapy?

A

-encourage patient to get as much reliable information about the herbal remedy (indications for use, interactions, possible side effects)

45
Q

What should our patients know before choosing a non-Rx product?

A
  • Will it affect blood glucose levels?
  • Does it interact with diabetes medications?
  • Are the ingratiates safe for a person with diabetes to use safely?
46
Q

How do you use NHPs safely ?

A
  • Work with/inform healthcare providers
  • Products with NPN number or EN number
  • Encourage single ingredient products
  • Encourage small starting dose determine effects/side effects
  • Help patients learn to spot false claims
  • Avoid products and promoters who make claims such as quick and effective cure-all, totally safe, all natural and no side effects, no risk, money back guarantees
47
Q

Are NHPs recommended for diabetes?

A

NHPs are not recommended for glycemic control for individuals with diabetes as there is insufficient evidence, at this time, regarding efficacy and safety
-HCPs should ask about the use of these NHPs

48
Q

Summary of NHPs

A
  • Natural is not always safe
  • New regulations
  • Little scientific evidence - help patients investigate
  • Potential to affect blood glucose
  • Encourage use with not instead of conventional meds
  • Encourage blood glucose monitoring
  • Encourage recording effects; if no results discontinue