1 General Path T Flashcards
What is phenotypic mixing?
cell infected by 2x viruses. Progeny takes capsid of one and genome of the other
What Rx’s are metabolized by methylation?
azathioprine & 6-mercaptopurine
How is Isoniazid metabolized?
acetylation
Rx’s cleared in the liver tend to have high what?
lipophilicity and Vd (high lipophilicity results in high Vd - can cross barriers easily)
What are the respective functions of each ribosomal subunit?
40s - binds mRNA & tRNA
60s - contains peptidyl transferase to forge peptide bonds
How to calculate Vd?
amount of Rx given/plasma conc. of Rx
How is Leber hereditary Optic Neuropathy inherited?
mitochondrial inheritance
What allows influenza virus to undergo genetic reassortment?
Segmented genome (like rotavirus)
B.O.A.R. acronym
Bunya Ortho Arena Reo families
What type of medium is N. gonococcus cultured on?
Theyer-Martin VCN (vancomycin/colistin/nystatin) - selective media
What are some common findings with antimuscarinic medications?
flushed cheeks and dilated pupils
What are Beer’s criteria and what’s included?
Rx’s to avoid in elderly; includes - alpha blockers, 1st gen histamines, TCA’s,
In what stage are the eggs of a female until puberty?
meiosis I
What phase progression does the egg undergo from FSH stimulation?
progresses from paused meiosis I to metaphase II
What stage is the egg in upon fertilization?
metaphase II
What is Bloom syndrome?
defect in BLM gene (helicase) resulting in photosensitive rash, microcephaly, growth retardation
