1 Allergy/Immuno T Flashcards
What are some side effects of 1st gen anti histamines?
AntiMusc - constipation, urine retention, blurry vision
AntiAdrenergic (alpha) - dizziness, postural hypotension
Antiserotinergic - appetite stimulation, weight gain
What is pathognumonic for Wagner’s?
cANCA; nasal ulceration w/ renal involvement
How can you get angioedema?
hereditary loss of C1 esterase inhibitor; Rx induced (ACEi): all lead to bradykinin increases
What are the symptoms of angioedema?
typically dry cough/swelling of lips/face/tongue; Can affect GI (colicky pain w/ nausea and diarrhea) & respiratory tree (difficulty breathing)
How does S. pneumo become pathogenic?
Tranformation allowing capsule formation
What are the symptoms of Henloch-Schloen?
Purpuric rash (small vessel vasculitis)
What substance is released along with histamine in anaphylactic reactions?
tryptase from MC’s, it’s often used to determine if an anaphylactic reaction has occurred
What happens with ankylosing spondylitis patient following GU infection?
uveitis/reactive arthritis/conjunctivitis; can also have palm/sole rash and sacroillitis
Antimitochondrial antibodies are specific for what?
primary biliary cirrhosis; jaundice, pruitis, hypercholesterolemia, hepatosplenomegaly
What is rheumatoid factor?
IgM directed against Fc of IgG
Anticentromere antibodies are in what?
CREST
Anti-sheep RBC are in what?
monospot test; infectious mononucleosis
What is calcinurin’s role in Tcell proliferation/differentiation?
calcineurin will dephosphorylate/active NFAT which will act as TF and increase IL-2
