034 Apparent Mineralcorticoid excess Flashcards
1
Q
What component in liquorice causes apparent mineralocorticoid excess syndrome?
A
Glycyrrhetinic acid –> acts on the type 1 mineralocorticoid receptor
2
Q
What is Barker’s hypothesis?
A
Intrauterine growth restriction will cause later complications such as CHD, diabetes
3
Q
What are the fates of testosterone?
A
- Into 5a-dihydrotestosterone by 5a reductase
2. Estradiol via P450 aromatase
4
Q
How is allopregnanolone formed and what are its effects?
A
From progesterone by 5a reductase and 3a HSD. It is a sedative neuroactive steroid and acts to potentiate actions of neurotransmitter GABA and GABAa receptor.
5
Q
How does fluoxetine work as an SSRI
A
Prevents conversion of allopregnanolone back to progesterone, reducing fluctuations that cause anciety
