016 Growth hormone cases

Question 1

How do you treat classic idiopathic growth hormone deficiency?

Answer 1

intramuscular GH injection 5-6 day regime if sufficient window of prepubertal time for catch up growth.

Question 2

What type of inheritence is laron syndrome?

Answer 2

Autosomal recessive

Question 3

How would you differentiate Larons syndrome using GH/ IGF1

Answer 3

Normal GH but low IGF1

Question 4

What are complications of larons syndrome?

Answer 4

Intra uterine growth retardation
deafness, mental retardation
GH resistance
Post natal growth failure

Question 5

Which chormosome is FGFR3 found on?

Answer 5

Chromosome 4

Question 6

Which transition is most commonly found on FGFR3 mutations in achondroplasia?

Answer 6

G–> A transition

Question 7

What are some complications of achondroplasia?

Answer 7

Ear infections
Sleep apnoea
Hydrocephalus
Spinal compression

Question 8

How would you treat acromegaly?

Answer 8

Bromocriptine D2 antagonist
Octeotride Somatostatin analoge
Surgery