010 CAL pathophysiology of diabetes Flashcards by Glenda Xu | Brainscape

Q

How does preproinsulin form insulin

A

Preproinsulin from chromosome 11
Preproinsulin cleaved at N terminus to generate proinsulin
Proinsulin cleaved from C peptide
Forms 51 amino acid insulin

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Q

How is insulin packaged for secretion

A

Hexamers coordinated by Zn and surrounded by C peptide

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Q

What is the minimum delay between preproinsulin mRNA and increase insulin secretion?

A

3 hours

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