008 An overview of Diabetes Mellitus Flashcards
1
Q
What is impaired glucose tolerance?
A
Fasting plasma glucose is <7mmol/L
75g 2 hour OGTT is >7.8 but <11.1 mmol/L
2
Q
What is impaired fasting glycaemia?
A
When fasting plasma glucose is >6.1 but below 7mmol/L
3
Q
What do glifozins do?
A
Inhibition of SLGT2 to prevent reuptake in the kidney
4
Q
What do gliptins do?
A
Increase GLP-1 to sensitize beta cells.
5
Q
What do a-glucosidase inhibitors do?
A
Inhibit glucose absorptions
6
Q
What do GLP-1 analogues do?
A
Pancrease insulin absorption
7
Q
How does rapid acting insulin work?
A
Prevent insulin hexamerisation
8
Q
How does slow acting insulin work? (2 methods?)
A
Bind to albumin or slow depots in the skin
9
Q
What type of insulin is Degludec
A
Long term
10
Q
What genetic inheritance pattern is MODY?
A
Autosomal dominant
