029 Catecholamines Flashcards

1
Q

What enzyme converts tyrosine into dopamine?

A

Tyrosine hydroxylase

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2
Q

What enzyme converts noradrenaline into adrenaline?

A

PNMT in the cytoplasm

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3
Q

What does cortisol control in catecholamine synthesis?

A

PNMT activity (NA—> Adrenaline)

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4
Q

What are the key end products of catecholamines?

A

VMA, metnephrine

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5
Q

What are the two mutations that occur in MEN?

A

Loss of MENIN tumor suprpessor

Gain of RET oncogene

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6
Q

What is the diffference betwen MEN2a and MEN2B

A

MEN2A includes parathyroid hormone

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7
Q

What is the difference between MEN1 and MEN2?

A

MEN1 are APUD cells not derived from neural crest, MEN2 are APUD cells derived from neural crest

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