029 Catecholamines Flashcards
1
Q
What enzyme converts tyrosine into dopamine?
A
Tyrosine hydroxylase
2
Q
What enzyme converts noradrenaline into adrenaline?
A
PNMT in the cytoplasm
3
Q
What does cortisol control in catecholamine synthesis?
A
PNMT activity (NA—> Adrenaline)
4
Q
What are the key end products of catecholamines?
A
VMA, metnephrine
5
Q
What are the two mutations that occur in MEN?
A
Loss of MENIN tumor suprpessor
Gain of RET oncogene
6
Q
What is the diffference betwen MEN2a and MEN2B
A
MEN2A includes parathyroid hormone
7
Q
What is the difference between MEN1 and MEN2?
A
MEN1 are APUD cells not derived from neural crest, MEN2 are APUD cells derived from neural crest
