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MT6320 > 02 NEISSERIA AND MORAXELLA > Flashcards

02 NEISSERIA AND MORAXELLA Flashcards

1
Q

Give the resut

Neisseria:
Cytochrome Oxidase
Catalase

A

Oxidase (+)
Catalase (+)

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2
Q

Shape and arrangement of Neisseria

A

Coffee bean/ Kidney in pairs

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3
Q

All Neisseria are diplococci except ___

A
  • N. elongata
  • N. bacilliformis
  • N. animaloris
  • N. weaveri
  • N. zoodegmatis

Appear as bacilli

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4
Q

Optimum temparature for Neisseria

A

32-36C

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5
Q

Neisseria spp. that require strict temperature condition

A
  • N. gonorrhoeae
  • N. meningitidis

35-37C (w/ additional iron)

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6
Q

All Neisseria spp. are catalase (+) except __

A
  • N. elongata
  • N. bacilliformis
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7
Q

Significant virulent factor of Neisseria

A

Endotoxin consisting of lipooligosaccharide

LOS instead of LPS

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8
Q

Pathogenic stains of Neisseria

A
  • N. meningitidis
  • N. gonorrhoeae
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9
Q

Identify the Neisseria spp.

Commensal inhabitant of the upper respiratory tract

A

N. meningitidis

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10
Q

Identify the Neisseria spp.

Not a part of human normal microbiota and may be obtained from scratch and bite of dogs and cats

A

N. animaloris

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11
Q

Additional requirement for fastidious Neisseria spp.

A
  • Factor X & V
  • Cysteine
  • Iron
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12
Q

Virulence factors of pathogenic Neisseria

Obtain iron from the host

A

Transferrin receptors

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13
Q

Virulence factors of pathogenic Neisseria

Antiphagocytic

A

Capsule

N. meningitidis

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14
Q

Virulence factors of pathogenic Neisseria

Adhesion and attachment

A

Pili (fimbriae)

N. gonorrhoeae

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15
Q

Virulence factors of pathogenic Neisseria (cell membrane protein)

Present in N. meningitidis

A

Por A & Por B

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16
Q

Virulence factors of pathogenic Neisseria (cell membrane protein)

Present in N. gonorrhoeae

A

Por B

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17
Q

Virulence factors of pathogenic Neisseria (cell membrane protein)

Adhesion to phagocytic cells and epithelial cells

A

Protein II (Opa)

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18
Q

Virulence factors of pathogenic Neisseria (cell membrane protein)

Blocks IgG action

A

Protein III (Rmp)

Prevent complement activity

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19
Q

Virulence factors of pathogenic Neisseria (cell membrane protein)

Fights inflammatory response and serum complement-mediated killing

A

Protein II (Opa)

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20
Q

Virulence factors of pathogenic Neisseria

Produces spots, rashes, bruises

A

Endotoxin (LOS)

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21
Q

Virulence factors of pathogenic Neisseria

Releases “blebs” during period of rapid growth

A

Endotoxin (LOS)

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22
Q

Virulence factors of pathogenic Neisseria

Damages tissue and elicits an inflammatory response

A

Endotoxin (LOS)

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23
Q

Identify the Neisseria spp.

Etiologic agent of the 2nd most common STD

A

N. gonorrhoeae

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24
Q

Identify the Neisseria spp.

Etiologic agent of acute pyogenic infection of nonciliated columnar and transitional epithelium

A

N. gonorrhoeae

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25
# Identify the *Neisseria spp.* Etiologic agent of ophthalmia neonatorum
*N. gonorrhoeae*
26
Manifestation of *N. gonorrhoeae* in women that is presented as perihepatitis affecting Glisson's capsule
Fitz Hugh Curtis Syndrome
27
DOC for ophthalmia neonatorum
Erythromycin
28
Main pathogenic factor of *N. gonorrhoeae*
Pili
29
Pathogenic strain of *N. gonorrhoeae*
T1 & T2 | presence of pili
30
Non-pathogenic strain of *N. gonorrhoeae*
T3, T4, T5
31
DOC for *N. gonorrhoeae*
Ceftriaxone
32
DOC for *N. gonorrhoeae* + *C. trachomatis*
Ceftriaxone + Azythromycin
33
# Identify the *Neisseria spp.* MOT: Droplet infection
*N. meningitidis*
34
# Identify the *Neisseria spp.* More common in crowded areas and colder months
*N. meningitidis*
35
# Identify the *Neisseria spp.* 2nd most common cause of meningitis among persons aged 2-18
*N. meningitidis* | 1st - *S. pneumoniae*
36
A condition caused by *N. meningitidis* that causes hemorrhage on adrenal gland, intravenous coagulation, and death within 12-48 hours
Waterhouse-Friderichsen Syndrome
37
DOC for *N. meningitidis*
Penicillin Cephalosporin (meningococcemia)
38
T/F: AST is not routinely performed in *N. meningitidis*
T
39
# Identify the *N. meningitidis* serotype Underdeveloped countries
A
40
# Identify the *N. meningitidis* serotype In developed countries such as the US and Europe
B
41
# Identify the *N. meningitidis* serotype In rare cases may cause pneumonia on adults
* Y * W1235
42
# Identify the *N. meningitidis* serotype Common in US
* C * Y
43
# Identify the *N. meningitidis* serotype Invasive
W135
44
# Laboratory dx. (*N. gonorrhoeae)* Specimen of choice for men
Urethral discharge | others: rectum, pharynx, synovial fluid, blood, CSF
45
# Laboratory dx. (*N. gonorrhoeae)* Specimen of choice for women
Endocervical discharge | others: rectum, pharynx, synovial fluid, blood, CSF
46
# Laboratory dx. (*N. gonorrhoeae)* Manners of collection
* Swab * Aspirates * Blood culture * Lumbar tap
47
# Laboratory dx. (*N. gonorrhoeae)* Clear fluids more than 1mL must be centrifuged at ___ (temp.), ___ (g), at for ___ (time)
room temp 1500 g 15 mins
48
# Transport media for *N. gonorrhoeae* Modified Thayer Martin w/ CO2 generator
JEMBEC Plate
49
# Laboratory dx. (*N. gonorrhoeae)* Pattern of cross-streaking
Z-pattern
50
# Laboratory dx. (*N. gonorrhoeae)* Transport medium used to allow direct plating
* JEMBEC Plate * Gono-Pak * Transgrow
51
# Laboratory dx. (*N. gonorrhoeae)* Used transport medium if immediate plating is not possible
Amie's medium with charcoal
52
# Laboratory dx. (*N. gonorrhoeae)* T/F: After gram staining of male samples, confirmatory biochemical tests are done
F | gram staining is already presumptive for MALE PX.
53
# Laboratory dx. (*N. gonorrhoeae)* Medium of choice
CAP w/ inhibitors | vancomycin, colistin, antifungal agents
54
# Laboratory dx. (*N. gonorrhoeae)*; identify the medium * Vancomycin * Colistin * Nystatin
Thayer Martin
55
# Laboratory dx. (*N. gonorrhoeae)*; identify the medium * Vancomycin * Colistin * Nystatin * Trimethoprim
Modified Thayer Martin | trimethoprim prevents swarming
56
# Laboratory dx. (*N. gonorrhoeae)*; identify the medium * Vancomycin * Colistin * Trimethoprim * Anisomicin
Martin Lewis | anisomicin is used instread of nystatin
57
# Laboratory dx. (*N. gonorrhoeae)*; identify the medium * Vancomycin * Colistin * Trimethoprim * Amphtericin B
New York City Agar | Mycoplasma & Ureaplasma may also grow
58
# Laboratory dx. (*N. gonorrhoeae)*; identify the medium * Vancomycin * Lincomycin * Colistin * Amphotericin B * Trimethroprim
GC LECT
59
# Laboratory dx. (*N. gonorrhoeae)* Differentiates *Neisseria* from *Kingella* & *Acinetobacter*
10-unit Penicillin disk
60
# Laboratory dx. (*N. gonorrhoeae)* Presumptive test for *N. gonorrhoeae*
Superoxol test
61
# Laboratory dx. (*N. gonorrhoeae)*; immunologic test Principle: coagglutination Uses antibodies to detect carrier strains of *S. aureus*
Phadebact
62
# Laboratory dx. (*N. gonorrhoeae)*; immunologic test Principle: colorimetry Detects soluble particles
GonoGenII
63
# Laboratory dx. (*N. gonorrhoeae)*; immunologic test Uses fluorescein-labelled antibodies
MicroTrak assay
64
Incubation conditions of *N. gonorrhoeae*
35C in 3-5% CO2
65
Incubation conditions of *N. gonorrhoeae*
5-10% CO2; within 18-24 hrs
66
*M. catarrhalis* is formerly known as ___
*Branhamella catarrhalis*
66
:)
67
3rd most common cause of otitis media
*M. catarrhalis*
68
Has "hockeypuck" consistency
*M. catarrhalis*
69
Older colonies of *M. catarrhalis* appear ___
Wagon wheel
70
Optimum growing temperature for *M. catarrhalis*
28C
71
Laboratory dx. that differentiates *Neisseria* from *M. catarrhalis*
CHO test | *M. catarrhalis*: asaccharolytic
72
# Identify the commensal *Neisseria* Mistaken for *N. gonorrhoeae* but grows on BAP
*N. cnerea*
73
# Identify the commensal *Neisseria* Causes nosocomial pneumonia; susceptible to colistin
*N. cinera* | *N. gonorrhoeae* is colistin (R)
74
# Identify the commensal *Neisseria* Yellow pigmented
*N. flavescens*
75
# Identify the commensal *Neisseria* Uses lactose
*N. lactamica*
76
# Identify the commensal *Neisseria* Large colonies; very mucoid; causes pneumonia
*N. mucosa*
77
# Identify the commensal *Neisseria* Produces large amounts of extracellular polysaccharide in media containing 1% to 5% sucrose
*N. polysaccharea*
78
# Identify the commensal *Neisseria* Dry, wrinkled; breadcrumb like colonies
*N. sicca*
79
# Identify the commensal *Neisseria* Less yellow pigmented colonies
*N. subflava*
80
# Identify the commensal *Neisseria* Rod shaped
*N. elongata*
81
# Identify the commensal *Neisseria* Normal flora on dogs; potential pathogen that has reported cases of septicemia among immunocompromised
*N. weaveri*

MT6320 (10 decks)

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