02 - Blood Flashcards

1
Q

Blood represents what percentage of body weight?

a) 8%
b) 2%
c) 0.8%
d) 20%

A

a) 8%

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2
Q

Blood preserves acid-base…

A

Homeostasis ⚖️

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3
Q

Blood distributes solutes such as…

A
  • Hormones
  • Ions
  • Nutrients
  • Metabolic waste
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4
Q

The 3 main constituents of blood, suspended in the plasma, are…

A
  1. Erythrocytes (‘red blood cells’)
  2. Leukocytes (‘white blood cells’)
  3. Thrombocytes (platelets)
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5
Q

Haematocrit is a measure of…

A

Red blood cell volume

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6
Q

Normal haematocrit is…

A

42% for women and 45% for men

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7
Q

Plasma is 90%…

A

Water 💦

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8
Q

Plasma proteins (4)…

A
  1. Serum albumin
  2. Globulins
  3. Fibrinogens
  4. Regulatory proteins
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9
Q

Serum albumin helps maintain…

A

Osmotic pressure

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10
Q

Serum albumin is involved with the transport of…

A

Lipids and steroid hormones

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11
Q

Serum albumin is produced in the..

A

Liver

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12
Q

Globulins transport…

A

Ions, hormones and lipids

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13
Q

Globulines also include…

A

Immune proteins

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14
Q

The levels of various plasma proteins can be identified by using…

A

Electrophoresis

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15
Q

Cirrhosis is…

A

Low levels of albumin and clotting factors

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16
Q

Low levels of albumin in cirrhosis is associated with…

A

A lack of osmotic control leading to severe edema known as “ascites”

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17
Q

The gross structure of an erythrocyte can be described as a…

A

Biconcave disk

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18
Q

The structure of erythrocytes enhances their…

A

Surface area to volume ratio

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19
Q

Erythrocytes contain enzymes, haemoglobin, cytosol but no…

A

Mitochondria or nucleus

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20
Q

Red blood cells may be too small (microcytic) as the result of…

A

Iron deficiency anaemia

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21
Q

Red blood cells may be too large (macrocytic) as the result of…

A

Folate (B9) deficiency anaemia

22
Q

Mean cell volume (MCV) is…

A

80-96 fL (femtolitres = 10^-15 L)

23
Q

Synthesis of erythrocyctes begins in the…

A

Bone marrow 🦴

24
Q

Erythrocytes originate from which cell type?

A

Multipotential hemopoietic stem cells known as hemocytoblasts

25
When producing erythrocytes, hematopoietic stem cells mature into...
Erythrocyte CFUs
26
Erythrocyte CFUs require EPO to form...
Proerythroblasts
27
Red blood cells enter the blood stream as...
Reticulocytes
28
In the late erythroblast stage the nucleus shrinks and is...
Is ejected (along with other organelles)
29
Reduced O2 in blood leads to the release of what substance from the kidney?
EPO | which stimulates bone marrow conversion of Erythrocyte CFU to proerythroblasts
30
The erythrocyte synthesis feedback loop takes around...
26 days 🗓
31
Erythrocytes have a life span of approximately...
120 days
32
Damaged RBCs are brought to the spleen and liver by...
Monocytes
33
Haemoglobin from RBCs is broken down into...
Haem and globin
34
G6PD deficiency reduces glutathione. This means...
No antioxidant in RBCs, damage is accumulated rapidly due to oxidative stress, predisposed to haemolytic crisis
35
G6PD deficiency is also known as...
Favism
36
The structure of the haem group is a...
Porphyrin ring with 1 iron atom
37
Adult haemoglobin usually contains which subunits?
2 alpha and 2 beta
38
Fetal haemoglobin usually contains which subunits?
2 alpha and 2 gamma
39
Cooperative binding means...
Subsequent O2 molecules are bound or released more readily
40
Haemoglobin has 2 forms...
* Relaxed (r) | * Taught (t)
41
Haemoglobin relaxed has...
High O2 affinity, firmly binding O2 in regions of high pO2 (such as in the lungs)
42
Haemoglobin taught has...
Low O2 affinity, releases O2 in regions of low pO2, i.e. peripheral tissues
43
In addition to oxygen, haemoglobin can also bind (4)...
CO2, H+, CO, NO
44
Sickle cell anaemia is an example of a...
Haemoglobinopathy (misfolded proteins)
45
In thalassemias, haemoglobin proteins are normal but...
Present in reduced numbers 🔻
46
Sickle cell anaemia results from a mutation in the...
Beta-globin gene (from Glutamic acid -> Valine)
47
In sickle cell anaemia the reduced lifespan of malformed RBCs results in...
Anaemia
48
Sickle cell trait is typically asymptomatic and protects against...
Malaria 🦟
49
Thalassemias are...
Recessive genetic diseases
50
In alpha thalassemia, the body compensates...
By producing more beta chains, which form a beta tetramer 'golf ball' ⛳️
51
Alpha thalassemia is found as trait (heterozygous) as the major form is...
Incompatible with life 💀
52
Beta thalassemia causes...
Iron overload leading to organ damage