01 - Homeostasis and the autonomic nervous system Flashcards

1
Q

Physiology can be defined as the study of the…

A

Body’s internal workings

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2
Q

Homeostasis is the maintanence of equilibrium through…

A

Compensation

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3
Q

Homeostasis involves the control of the…

A

Internal environment (ECF)

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4
Q

Homeostasis maintains variables…

A

Witihin a limited range

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5
Q

Homeostasis involves the intergrated function of…

A

Different organ systems

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6
Q

Diseases result from a failure to maintain…

A

Homeostasis

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7
Q

Homeostatic control is a continous process that involves monitoring…

A

Multiple parameters

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8
Q

a) Sensor -> stimulus -> controller -> effector -> response b) Stimulus -> sensor -> effector -> controller -> response c) Stimulus -> sensor -> controller -> effector -> response d) Controller -> stimulus -> sensor -> effector -> response

A

c) Stimulus -> sensor -> controller -> effector -> response

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9
Q

Physiological control mechanisms can be classified as (3)…

A

• Nervous system • Endocrine • Paracrine

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10
Q

Despite neuroendocrine pathways being grouped into 3 types there are actually…

A

No absolute distinctions between them

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11
Q

A major function of the Autonomic Nervous System (ANS) is to maintain…

A

Homeostasis

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12
Q

ANS control centres are located in the (3)…

A
  1. Hypothalamus 2.Brain stem 3. Spinal cord
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13
Q

Efferent pathways of the ANS are divided into (2)…

A

• Sympathetic (‘fight or flight’) • Parasympathetic (‘rest and digest’ or ‘feed and breed’)

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14
Q

The structure of the NS can be divided into 3 main parts…

A
  1. Pre-ganglionic neurone 2. Autonomic ganglion 3. Post-ganglionic neurone
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15
Q

The parasympathetic NS is characterised structurally by…

A

Long pre-ganglionic and a short post-ganglionic neurone

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16
Q

The sympathetic NS is characterised structurally by…

A

Short pre-ganglionic and a long post-ganglionic neurone (and the existance of the sympathetic ganglia)

17
Q

The pre-ganglionic origin of the parasympathetic NS (2)…

A
  1. Cranial nerves (III, VII, IX, X) 2. Pelvic nerve
18
Q

The pre-ganglionic origin of the sympathetic NS is (2)…

A
  1. Thoracic 1 (T1) 2. Lumbar 2/3 (L2/3)
19
Q

The origin of some post-ganglionic neurones in the sympathetic ANS is the…

A

Autonomic ganglia

20
Q

The autonomic ganglia is comprised of 2…

A

Paravertibral sympathetic chains

21
Q

The adrenal medulla is directly innervated by…

A

Pre-ganglionic neurones from the sympathetic NS

22
Q

Neurotransmitters of the ANS (4)

A

• Acetylcholine • Noradrenaline (norepinephrine) • Adrenaline (epinephrine) • NANC

23
Q

ANS receptors (2)…

A

• Cholinergic • Adrenergic

24
Q

Nicotinic Ach receptors can be found at the…

25
Cholinergic receptors are divided into (2)...
• Muscarinic (can bind to muscarinol) • Nicotinic (can bind to nicotine)
26
Muscarinic Ach receptors can be blocked by...
Atropine, leading to pupil dilation
27
Nicotinic Ach receptors can be blocked by...
Curare, leading to muscle relaxation or death at higher doses (?)
28
Adrenergic receptors can be divided into (2)...
• alpha 1 & 2 • beta 1 & 2
29
Propanolol blocks the...
Beta adrenoreceptors
30
Alpha adrenoreceptors have greater affinity for...
Noradrenaline relative to adrenaline
31
Beta 1 adrenoreceptors have... a) equal affinity for adrenaline vs noradrenaline b) higher affinity for noradrenaline c) higher affinity for adrenaline
a) equal affinity
32
Beta 2 adrenoreceptors have a greater affinity for...
Adrenaline relative to noradrenalin
33
Alpha adrenoreceptors can be blocked by...
Phentolamine
34
Alpha 1 adrenoreceptors are ( pre / post ) synaptic and result in vasoconstriction and smooth muslcle contraction.
Alpha 1 adrenoreceptors are post-synaptic
35
Alpha 2 adrenoreceptors are ( pre / post ) synaptic and (increase / reduce) cholinergic and adrenegric effects.
Alpha 2 adrenoreceptors are pre-synaptic and reduce cholinergic and adrenergic effects
36
Examples of pharmocological agents used to study the role of specific neurotransmitters (4)...
• Curare (blocks nicotinic-cholinoreceptors) • Atropine (blocks muscarinic-cholinoreceptors) • Phentolamine (blocks alpha-adrenoreceptors) • Propanolol (blocks beta-adrenoreceptors