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Micro > Zoonotics > Flashcards

Zoonotics Flashcards

1
Q

Rickettsiae morphology

A 
Giemsa stain rods
peptidoglycan containing cell wall
diaminopimelic acid (DAP) cell wall
obligate intracellular
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2
Q

rickettsiae virulence

A

multiply in endothelial cells –> leakage and thrombosis

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3
Q

Rickettsiae Dx

A 
#1--> serology
#2 --> PCR assay
#3 --> Weil-Felix reaction = not used d/t cross reactivity with Proteus
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4
Q

Rickettsiae Tx

A

sulfonamides will make it WORSE!
PNC doesn’t work
use tetracyclines or chloramphenicol

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5
Q

R. Rickettsii

A

Rocky Mountain Spotted Fever
xsmitted by the wood and dog tick (Dermacentor)
Rocky mountain rgn / Eastern and SE US
rash on trunk, soles, and palms

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6
Q

R. Rickettsii complications

A 
DIC
thrombocytopenia
encephalitis
vascular collapse
renal and cardiac failure
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7
Q

R. akari

A

Rickettsial pox
xsmitted by house mouse mite
US large urban areas / Russia / Korea

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8
Q

R. akari clinical presentation

A

erythematous papules –> vesicles –> local eschar with regional lymphadenopathy

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9
Q

R. prowazekii

A

Endemic typhus
Res: humans and flying squirrels
Xsmitt via human body and head louse
Central, South America and Africa

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10
Q

R. prowazekii clinical presentation

A

2wks –> H/M/F –> 4-7d –> patchy cutaneous erythema –> maculopapular, petechial, or hemorrhagic form
rash starts at trunk and goes to extremities
does not affect the soles or palms

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11
Q

R. prowazekii complications

A 
Brill-Zinsser Dz = recrudescent infection
myocarditis
CNS dysf(x)
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12
Q

R. typhi

A

Endemic (murine) typhus
Res: rat
Xsmit via rat flea (Xenopsylla)
rash that starts on trunk and spreads to the extremities

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13
Q

Oriental (R.) tsutsugamushi

A 
Scrub typhus
Res: rodents
Xsmit via chiggers
chills/F/H --> local vesicular lesion --> black eschar
fatality 30% in untreated cases
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14
Q

Ehrlichia

A

Ehrlichiosis
Res: cattle, domestic animals
Xsmit via deer and dog ticks
SE, Mid Atlantic, S, Central US

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15
Q

Ehrlichia clinical presentation

A

Rash is UNCOMMON
F/H/M/Myalgia
leukopenia
thrombocytopenia

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16
Q

Yersinia pestis

A

Bubonic plague
SE US –> semi-arid plains
G- rods
bipolar staining via Giemsa stain

17
Q

Yersinia pestis virulence

A

facultative intracellular parasite of macrophages
V-W antigens = antiphago
F1 antigens = antiphago
Type III secretion system –> Yops

18
Q

Yersinia pestis pathogenesis

A
  • bubonic vs pneumonic (highly contagious)
  • xsmit via flea bite, human contact, resp xsmission
  • organisms infect lymphatics –> hemorrhagic and supurative necrosis –> bubo formation
19
Q

Yersinia pestis Tx

A

streptomycin and gentamicin
recovery = long lasting immunity d/t CMI and opsonizing Ab
formalin-killed vaccine no longer used in US

20
Q

Francisella tularensis

A 
tularemia / rabbit fever / deerfly fever / rabbit skinner's dz
G- coccobacillus
growth on sulfhydryl compound media
facultative intracellular
Dx via serology
Tx with strepto or gentamicin
long lasting CMI upon recovery
attenuated partially protective vaccine available
21
Q

Francisella tularensis pathogenesis

A
  • infection –> invasion of macro, necrosis and GRANULOMA formation
  • ulceroglandular = most common / ulcerating, necrotic plaque
  • glandular = vector borne / regional lymph enlargement / no skin lesions
  • oculoglandular = conjunctivitis with lymph involvement
  • typhoidal = most severe / bacteremia with organ seeding / resembles TB or brucellosis
22
Q

Brucella (suis, abortus)

A 
brucellosis (undulant or Malta fever)
G- coccobacilli
aerobic
catalase and oxidase +
growth on trypticase-soy agar w/ CO2
facultative intracellular
23
Q

Brucella (suis, abrotus)

A 
Xsm: contam milk, droplets, skin contact
mult in phago cells --> nodes --> blood --> organ seeding
GRANULOMATOUS nodules and abscesses
undulating fever with night sweats
palpable spleen
Dx via serology via agglutination
24
Q

Pasteurella multocida

A

cat-scratch disease
G- coccobacilli
non-hemolyitic mucoid colonies on blood agar
diffuse cellulitis w/ erythematous border

Micro (19 decks)

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