Meningitis

Question 1

Newborn bacterial meningitis

Answer 1

Group B strep –> S. agalactiae
E. coli
Listeria monocytogenes

Question 2

Infant bacterial meningitis

Answer 2

N. meningitidis
H. influenzae
S. pneumoniae

Question 3

Childhood bacterial meningitis

Answer 3

N. meningitidis

S. pneumoniae

Question 4

Adult bacterial meningitis

Answer 4

S. pneumoniae
N. meningitidis
Mycobacteria

Question 5

Group B strep = S. agalactiae

Answer 5

leading cause of sepsis, meningitis, and pneumonia in newborns
G+ cocci
extracellular; short chains or pairs
beta hemolytic; a few are non-hemolytic
sialic acid polysaccharide capsule –> prev C3 deposition

Question 6

Group B strep patho

Answer 6

type III most common serotype (I and II also cause dz)
starts off as pneumonia and can progress to meningitis
hippurate positive–> deep purple color
post CAMP test
catalase -
Tx with PCN

Question 7

N. meningitidis

Answer 7

G- diplococci
cat and ox +
maltose and glc fermenter
Epid: human only host
spread via airborne droplets
inc dz seen in pt with term C' def
maternal Ab protects until 6mo
Complication: Waterhouse-Frid --> destruction of adrenal glands

Question 8

N. meningitidis virulence

Answer 8

polysaccharide capsule --> antiphago
endotoxin/LPS
IgA protease
Pili
Adhesins
Invasins
Xsferrin and lactoferrin binding proteins