URT viruses Flashcards
Rhinovirus
#1 common cold #2 acute laryngitis picornavirus nonenv ss+ RNA grows better at 33deg SEVERAL serotypes winter
Xsmit of resp viruses
direct contact
contact with secretions
airborne
resp virus patho
inoculation through URT
eyes and nose are sensitive
cells are destroyed and denuded
trigger immediate hypersensitivity –> virus-induced wheezing and asthma
Coronavirus
#2 common cold env ss+ RNA has viral encoded RNA dep RNA poly codes nested subgenomic mRNA only 2 serotypes includes SARS winter and spring
Adenovirus
nonenv ds dna fibers from capsid types 4 and 7 in military recruits --> live vaccine available year round infections common in kids Dx with PCR maternal Ab do not protect
Influenza
#2 pneumonia orthomyxovirus env segmented ss- RNA spikes that contain H (entry) and N (release) undergoes genetic shift and drift replicates in nucleus
Influenza epdi
types B & C are humans only
type A is found in other animals as well
winter months
Influenza patho
type A more likely to be fatal
sim dz in type B and C
type B –> intestinal
Influenza complications
primary flu viral pneumonia bacterial superinf cytokine storm --> ARDS reyes syndrome --> aspirin Guillian-Barre otitis media
Influenza vaccine
killed IM = >65yo
killed ID = 18-64
live, attenuated = 2-49yo; nasal
Parainfluenza virus
Croup --> barking seal coughe env ss-RNA Fusion and HN proteins rep only in resp epith cells viral shedding for about a week
Parainfluenza virus CP
#1 croup #2 bronchiolitis and pneumonia reinfections common 50% of kid are infected with HPIV-3 during the first year of life maternal Ab not protective
Resp Syncytial Virus
NO H or N
#1 in bronchiolitis and pneumonia in infants under 1yr
PTP contact xsmission only
winter and early spring
form multinucleate syncytial cells in tracheobrinchial
IgG not protective
