Resp Fungi

Question 1

Histoplasma capsulatum

Answer 1

Histoplasmosis
Ohio and Mississippi river valleys
inhalation of asexual spores
facultative intracellular
yeast cells in lung macrophages form granulomas

Question 2

Histoplasma capsulatum Dx and Tx

Answer 2

Sabouraud’s aga –> sputum or tissue sample
see tuberculate chlamydospores at 25deg
most recover w/o Tx
ampho B in serious cases

Question 3

Coccidioides immitis

Answer 3

Valley Fever
dimorphic –> spherules with endospores at 37deg
arid regions of the US via inhalation of arthrospores
most virulent
flu-like illness

Question 4

Blastomyces dermatitidis

Answer 4

Blastomycosis
spores at 25deg
Broad Based Buds of yeast at 37deg
East of the Mississippi
decaying matter and soil

Question 5

Blastomycosis patho

Answer 5

abscess and granuloma formation

can disseminate to bone and skin

Question 6

Paracoccidioides brasiliensis

Answer 6

S. American Blastomycosis
pilot wheel morph --> daughter cells bud off of parent
major systemic mycosis in latin america
thrives in hot temps and acid soil
productive cough, lb loss, fever

Question 7

Zygomycetes/Mucormycosis

Answer 7

rapidly growing
broad hyphae with no septa
soil and decaying matter
air conditioning systems and construction sites
risk to diabetics and those with neutrophenia

Question 8

Zygomycetes/Mucormycosis PATHO

Answer 8

pulmonary –> primary inf in neutropenic pt; invasion and infarct of vessels
rhinocerebral –> nasal sinuses –> CNS; diabetics with DKA and hematologic malig
angioinvasive