Persistent infections of the CNS

Question 1

Measles virus

Answer 1

Subacute Sclerosing Panencephalitis (SSPE)
rare complication of the measles
demyelinating dz due to absent M protein–> inhibition of virion release
anti-measles Ab in CSF but NO M protein Ab

Question 2

JC virus

Answer 2

Progressive multifocal leukoencephalopathy (PML)
papovavirus
ds circular DNA virus
immunosuppression causes reactivation of dz

Question 3

Prions

Answer 3

CJD
vCJD
Kuru

Question 4

Nocardia asteroides

Answer 4

G+ partially acid fast
filamentous bacteria
aerobic
found in soil --> direct inoculation
lobar pneumonia that can disseminate to brain, kidneys, and skin
Tx with sulfonamides