Zinc

Question 1

what is zinc essential for and what is the common cause of poisoning?

Answer 1

growth and reproduction

pennies

Question 2

What is the absorption/distribution?

Answer 2

zinc is wel absorbed
- carrier mediated transport

found in most tissues
level influenced by nutritional status, metal interactions and infectious disease

Question 3

What is the excretion?

Answer 3

excreted in the urine and bile
excess zinc eliminated in 2-3d
if kidney damage excretion is impaired 1-3x

Question 4

What is the MOA?

Answer 4

causes oxidative damage

may occur

• hapten-induced
• immune dysfunction
• DIC

Question 5

what are the GIT clinical sings?

Answer 5

anorexia, salivation

vomiting, diarrhea and bleeding

Question 6

What are the liver clinical signs?

Answer 6

jaundice

Question 7

What are the blood clinical signs?

Answer 7

intravascular hemolysis
heinz bodies
leukocytosis with a left shift
regen enemia
bilirubinemia

Question 8

What are the kidney clinical signs?

Answer 8

hemoglobinuria

tubular necrosis

Question 9

What is the Dx of zinc?

Answer 9

elevated blood zinc levels (use proper collection tube)
radiographs
clin path (RBC)
- PVC decrease
- kidney BUN elevated
- pancreatic elevated enzymes
- amylase

Question 10

What will happen if you use normal tubes for blood collection?

Answer 10

enough zinc in tube to double the value?

Question 11

what is the treatment?

Answer 11

surgery (might die on table)
blood transfusion, fluids
heparin (prevent DIC) or dicoumaral)
H2 antagonist - reduced acid secretion in gut (penny break down reduced)
CaEDTA (use great caution)
penicillamine (chelation)

Question 12

What are the complications of zinc?

Answer 12

pancreatitis

DIC