Wound Healing Flashcards

1
Q

A successful ____ maintains tissue function and repair tissue barrier, preventing blood loss and infection, but it is usually accomplished through collagen deposition or scarring

A

wound healing

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2
Q

Mention the steps of the basic processes of healing

A
  1. Hemostasis
  2. Inflammation process and cellular migration
  3. Cell proliferation
  4. Extracellular matriz organization and remodeling
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3
Q

Is the steps that control the bleeding in the injury

A

hemostasis

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4
Q

Type of hemostasis

A

Primary and secondary

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5
Q

Goal of the primary hemostasis

A

Platelet plug formation

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6
Q

Goal of the secondary hemostasis

A

Clot formation

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7
Q

Describe the process of primary hemostasis

A

Local vasoconstriction
Adhesion
Platelet activation
Aggregation

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8
Q

Mention the 3 pathways of secondary hemostasis

A

Extrinsic pathway
Intrinsic pathway
Common pathway

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9
Q

Extrinsic and intrinsic pathway both converge in

A

common pathway

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10
Q

____ allows the conversion between extrinsic and intrinsic pathway

A

Factor Xa

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11
Q

All the pathways of secondary hemostasis have in common the

A

Factor Xa

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12
Q

Cellular migration last

A

several days (3-5)

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13
Q

Steps of cellular migration

A
  1. Migration begins
  2. Angiogenic factor
  3. Pericyte migration
  4. Growth factors
  5. Reepithelization
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14
Q

Step of cellular migration that reclute cells from circulation or bone marrow

A

Migration begins

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15
Q

Step of cellular migration where monocytes, macrophages secrete grows factor to release the angiogenesis

A

Angiogenic factor

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16
Q

Step of cellular migration that stimulate the process of angiogenesis

A

pericyte migration

17
Q

Step of cellular migration where the fibroblast migrate to the wound

A

Growth factors

18
Q

Step of cellular migration where queratinocites penetrate the wound

A

Reepithelization

19
Q

Are important players facilitating the inflammatory proliferative phase transition during wound healing

A

Macrophages

20
Q

Excessive and prolonged inflammation result in _____ and increased scar formation

A

delayed healing

21
Q

There are an increased of neutrophils

A

inflammation

22
Q

There are an increased of anti inflammatory mediators and growth factors

A

proliferation

23
Q

Is the best moment to use NSAIDs

A

proliferation

24
Q

If the transition from inflammation to proliferation doesn’t exist the wound healing

A

does not occur

25
Q

Goal of the remodeling in wound healing

A

Achieve tensile strength

Recover the normal tissue structure

26
Q

The remodeling in wound healing begins ____ after the injury

A

2-3 weeks

27
Q

Mention the forms of tissue regeneration

A

Labile
Stable
Permanent

28
Q

Form of tissue regeneration where the wound heal well

A

labile

29
Q

Form of tissue regeneration where there is an hyperplasia

A

stable

30
Q

Form of tissue regeneration where there is a weak regeneration capacity

A

permanent

31
Q

Tissues where we can find a labile regeneration

A

Skin, connective tissue, intestine

32
Q

Tissues where we can find a stable regeneration

A

liver

33
Q

Tissues where we can find a permanent regeneration

A

Skeletal muscle, cartilage, neurons and cardiac tissue

34
Q

Types of skin healing

A

Primary intention
Secondary intention
Tertiary intention

35
Q

Type of skin healing where the wound edges come together

A

primary intention

36
Q

Type of skin healing where the wound edges are too far one to another and heal by themselves

A

secondary intention

37
Q

Type of skin healing where the wound is infected so we have to leave it open

A

tertiary intention

38
Q

Is when the injured tissue returns to its original state

A

regeneration