Wound Healing Flashcards
A successful ____ maintains tissue function and repair tissue barrier, preventing blood loss and infection, but it is usually accomplished through collagen deposition or scarring
wound healing
Mention the steps of the basic processes of healing
- Hemostasis
- Inflammation process and cellular migration
- Cell proliferation
- Extracellular matriz organization and remodeling
Is the steps that control the bleeding in the injury
hemostasis
Type of hemostasis
Primary and secondary
Goal of the primary hemostasis
Platelet plug formation
Goal of the secondary hemostasis
Clot formation
Describe the process of primary hemostasis
Local vasoconstriction
Adhesion
Platelet activation
Aggregation
Mention the 3 pathways of secondary hemostasis
Extrinsic pathway
Intrinsic pathway
Common pathway
Extrinsic and intrinsic pathway both converge in
common pathway
____ allows the conversion between extrinsic and intrinsic pathway
Factor Xa
All the pathways of secondary hemostasis have in common the
Factor Xa
Cellular migration last
several days (3-5)
Steps of cellular migration
- Migration begins
- Angiogenic factor
- Pericyte migration
- Growth factors
- Reepithelization
Step of cellular migration that reclute cells from circulation or bone marrow
Migration begins
Step of cellular migration where monocytes, macrophages secrete grows factor to release the angiogenesis
Angiogenic factor
Step of cellular migration that stimulate the process of angiogenesis
pericyte migration
Step of cellular migration where the fibroblast migrate to the wound
Growth factors
Step of cellular migration where queratinocites penetrate the wound
Reepithelization
Are important players facilitating the inflammatory proliferative phase transition during wound healing
Macrophages
Excessive and prolonged inflammation result in _____ and increased scar formation
delayed healing
There are an increased of neutrophils
inflammation
There are an increased of anti inflammatory mediators and growth factors
proliferation
Is the best moment to use NSAIDs
proliferation
If the transition from inflammation to proliferation doesn’t exist the wound healing
does not occur
Goal of the remodeling in wound healing
Achieve tensile strength
Recover the normal tissue structure
The remodeling in wound healing begins ____ after the injury
2-3 weeks
Mention the forms of tissue regeneration
Labile
Stable
Permanent
Form of tissue regeneration where the wound heal well
labile
Form of tissue regeneration where there is an hyperplasia
stable
Form of tissue regeneration where there is a weak regeneration capacity
permanent
Tissues where we can find a labile regeneration
Skin, connective tissue, intestine
Tissues where we can find a stable regeneration
liver
Tissues where we can find a permanent regeneration
Skeletal muscle, cartilage, neurons and cardiac tissue
Types of skin healing
Primary intention
Secondary intention
Tertiary intention
Type of skin healing where the wound edges come together
primary intention
Type of skin healing where the wound edges are too far one to another and heal by themselves
secondary intention
Type of skin healing where the wound is infected so we have to leave it open
tertiary intention
Is when the injured tissue returns to its original state
regeneration
