Hematologic disorders Flashcards
An abnormally low hemoglobin concentration in the blood
anemia
Types of anemia
Macrocytic
Normocytic
Microcytic
Types of macrocytic anemia
Megaloblastic
Non megaloblastic
Mention the causes of megaloblastic macrocytic anemia
Folic acid deficiency
Vitamin B12 deficiency
Drugs
Mention the causes of non megaloblastic macrocytic anemia
Alcohol
In macrocytic anemia the MCV is
increased
In microcytic anemia the MCV is
decreased
Mention the causes of microcytic anemia
Iron deficiency
Thalassemias
Chronic inflammatory disease
In normocytic anemia the MCV is
normal
Mention the causes of normocytic anemia with an increase of reticulocyte count
Hemolytic anemia
Blood loss
Mention the causes of normocytic anemia with a decrease of reticulocyte count
Bone marrow disorders
Aplastic anemia
MCV
Mean Corpuscular Volume
Is the estimated volumen of a single cell
MCV
Increased marrow activity
Neutrophilia
Decreased marrow activity
neutropenia
Uncontrolled proliferation of inmmature with blood cells
leukemia
Mention the 2 types of leukemia
acute and chronic
Leukemia is commonly caused by genetic mutations such as:
Chromosomal deletion
Trisomies
Translocation
Symptoms of leukemia are
anemia, thrombocytopenia, leukopenia, hepatosplenomegalu, lymphadenopathy
Type of leukemia where the cells don’t mature
acute
Type of leukemia where there is a proliferation of immature leukocytes
chronic
Mention the 2 most common examples of acute leukemia
Acute myeloid leukemia
Acute lymphoid leukemia
Acute myeloid leukemia is most common in
older adults
Acute lymphoblastic leukemia is most common in
children
Treatment of leukemia
allogenic stem cell transplantation, autologous stem cell transplantation, peripheral blood stem cell transplantation, bone marrow transplant
Lower platelets counts
Hypersplenism
Causes of platelets disorders
Hypersplenism
Platelet cosumtion
Immune-mediated consumtion
Is a hematology disease in wich is a decrease in any of the clot factor due to genetic mutations
hemophilia
There are 2 types of hemophilia
Hemophilia A
Hemophilia B
Is the most common X linked recessive type of hemophilia
Hemophilia A
The hemophilia B is
uncommon
The hemophilia A has a deficiency of
factor VIII
The hemophilia B has a deficiency of
factor IX