Wordsology Blood Bank High Yield Notes Flashcards
Write down the Weiner genotypes and match them to their corresponding Fisher-Race antigen phenotypes.
Weiner: Ro, R1, R2, Rz r, r’, r’’, ry
Fisher Race: Dce, DCe, DcE, DCE dce, dCe, dcE, dCE
Which two genes (Weiner) are the most common in the population?
R1 –> DCe
r –> dce
What percent of the population is Rh+?
85%
Asian’s are almost always what Rh type?
Asians are almost always Rh+ (D+)
What single Rh antigen is the most common in whites?
e
What single Rh antigen is the most common in Africans?
e** > c > D
e = 95%, c = 96% D = 92%
What single Rh antigen is the least common in whites?
E
What single Rh antigen is the least common in blacks
E (22%)
Followed closely by C (27%)
What two Rh phenotypes are the most commonly seen in whites?
- R1 = DCe (42%)
2. r = dce (37%)
What two Rh phenotypes are the most commonly seen in Africans/Blacks?
- Ro = Dce (44%)
2. r = dce (25%)
What two Rh phenotypes are the most commonly seen in Asians?
R1 = DCe (70%) R2 = DcE (21%)
Which Rh phenotypes are very uncommon?
Rz
r’’
ry
How is the Lewis system produced?
NOT produced by the red cell. They are ADSORBED onto the RBC from the plasma.
If only the Le gene is inherited and not the secretor gene, what antigen is adsorbed onto the RBCs and what is the phenotype?
Le ONLY
NO Secretor gene
Le(a) is adsorbed onto the RBCs!
Le (a+ b-)
If the Le gene AND secretor gene is inherited, what antigen is adsorbed onto the RBCs and what is the phenotype?
Le AND Secretor gene
Le(b) is adsorbed onto the RBCs!
Le (a- b+)
Which antibodies are naturally occurring?
ABO, Lewis, P1, MN, Lu(a)
Which antibodies are clinically significant?
ABO, Rh, Kell, Duffy, Kidd, SsU
Which antibodies are warm antibodies?
Rh, Kell, Duffy, Kidd
What antibodies are cold antibodies?
M, N, P1
What antibodies usually only react in AHG (not detected on immediate spin)?
Kell, Duffy, Kidd
What antibodies can react in any phase of testing?
Lewis
What antibodies can be ENHANCED by enzyme treatment?
Rh, Lewis, Kidd
What antibodies CANNOT be detected by enhancement of enzyme treatment?
M, N, Duffy
What antibodies can be ENHANCED by acidification?
M
Which antibodies show DOSAGE?
Rh (other than D), MNS, Duffy, Kidd
Which antibodies bind complement?
I, Kidd, Lewis
Which antibodies cause IN VITRO hemolysis?
ABO, Lewis, Kidd, Vell, and some P1
Which antibodies are labile (can change) in vivo and in vitro?
Kidd
What antibodies are a common cause of anamnestic response (delayed transfusion rxns)
Kidd
** Kids are delayed **
Which antibodies are associated with paroxysmal cold hemoglobinuria (PCH)?
Anti-P
What age does a donor have to be to give blood?
> or equal to 16
What weight does a donor have to be to give blood?
at least 110 lbs
Donor interval for whole blood?
8 weeks
Donor blood pressure?
less than or equal to 180/100
remember SKY over DIRT; systolic/diastolic
What does a blood donor’s pulse have to be for them to give blood?
50-100 bpm
Donor hemoglobin? (allogenic)
> or equal to 12.5
Donor hematocrit? (allogenic)
> or equal to 38%
Females > or equal to 36%
Males > or equal to 39%
Donor temperature?
< or equal to 37.5 or 99.5C
What is a cause of deferral for autologous donations?
Bacteremia
Calculation for how much blood can an autologous donor give themselves?
(Weight in Kg/50kg) x 450mL
