P and P1 Antibodies Flashcards
What type of antibody is Anti-P1?
IgM cold antibody, naturally occurring
What kind of antibody is Anti-P?
IgG auto-antibody. This is the Donath Landsteiner biphasic antibody found in Paroxysmal Cold Hemoglobinuria.
What cells does Anti-P react with?
Anti-P reacts with all P or P1 positive cells.
What happens to the P1 antigen upon storage?
P1 antigen strength deteriorates upon storage.
In regards to neutralization, what can you do with Anti-P1?
Anti-P1 can be neutralized to reveal other clinically significant alloantibodies.
(using Hydatid cyst fluid or pigeon egg whites)
Where can P1 substance be found in the human body?
Hydatid cyst fluid.
> > in animals can also be found in pigeon egg whites.
Which antibodies can be detected at immediate spin?
Any RT or cold antibodies: I, M, N, P1, Lewis (I may not pack lunch)
What P antibody can cause spontaneous abortions and is also associated with Paroxysmal Cold Hemoglobinuria?
Anti-P