P and P1 Antibodies Flashcards

1
Q

What type of antibody is Anti-P1?

A

IgM cold antibody, naturally occurring

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2
Q

What kind of antibody is Anti-P?

A

IgG auto-antibody. This is the Donath Landsteiner biphasic antibody found in Paroxysmal Cold Hemoglobinuria.

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3
Q

What cells does Anti-P react with?

A

Anti-P reacts with all P or P1 positive cells.

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4
Q

What happens to the P1 antigen upon storage?

A

P1 antigen strength deteriorates upon storage.

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5
Q

In regards to neutralization, what can you do with Anti-P1?

A

Anti-P1 can be neutralized to reveal other clinically significant alloantibodies.
(using Hydatid cyst fluid or pigeon egg whites)

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6
Q

Where can P1 substance be found in the human body?

A

Hydatid cyst fluid.

> > in animals can also be found in pigeon egg whites.

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7
Q

Which antibodies can be detected at immediate spin?

A

Any RT or cold antibodies: I, M, N, P1, Lewis (I may not pack lunch)

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8
Q

What P antibody can cause spontaneous abortions and is also associated with Paroxysmal Cold Hemoglobinuria?

A

Anti-P

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