Misc. Transfusion-Related Diseases

Question 1

What is more common - contamination of blood products with bacteria or viruses?

Answer 1

Bacterial.

Most tests now can detect viruses.

Question 2

What blood product must be tested for bacterial contamination before issuing?

Answer 2

Platelets

Question 3

What are the required tests by AABB and/or FDA for transmissible diseases?

Answer 3

** Hep B, Hep C, HIV, HTLV, West Nile Virus, Syphilis, Trypanosoma cruzi **

HBV DNA
HBsAg, Anti-HBc

HCV RNA
Anti-HCV

Anti-HIV-1/2
HIV-RNA

Anti HTLV-1/11

West Nile Virus RNA

Syphilis

Trypanosoma cruzi

Question 4

What is graft versus host disease?

Answer 4

When immunocompetent donor T cells attack the recipient’s lymphoid tissues

Question 5

Would graft versus host disease occur even if the recipient was heterozygous for an HLA haplotype was transfused with an HLA homozygous donor who has one matching haplotype?

Answer 5

Yes

Question 6

If a patient has a high fever with shaking chills and hypotension, what transfusion related event can you suspect?

Answer 6

Transfusion-related sepsis

Question 7

What is the purple of diversion pouches?

Answer 7

To reduce incidence of bacteria entering component.