Kell Antibodies

Question 1

What kind of antibodies are Kell?

Answer 1

IgG warm antibody

Question 2

What phase does Anti-K usually react in?

Answer 2

AHG 37C

Making it clinically significant

Question 3

Is being K positive or K negative more common?

Answer 3

K negative (do not have antigen K)
about 91% of people are K-

Question 4

What % of people are K negative?

Answer 4

91%

Question 5

What inactivates the Kell antigens?

Answer 5

2-ME, DTT, or AET

Question 6

Kell antigens are developed well and can be detected on fetal cells. T or F

Answer 6

True

Antigens develop at various rates both in utero and after birth. Kell blood group antigens can be detected on fetal cells at 10 weeks gestation and are well developed at birth.

Question 7

What is the rare phenotype found exclusively in male patients that is caused by X-linked inheritance from a carrier mother, often demonstrating a chronic but well-compensated anemia as well as muscle and nerve disorders?

Answer 7

McLeod

The correct answer is the McLeod phenotype, which also is indicated by a lack of the Kx and Km antigens, depressed expression of other Kell Blood Group antigens, and may be associated with X-linked chronic granulomatous disease (but this association is not always present).

Question 8

The McLeod phenotype is associated with which antigen systems?

Answer 8

Kell