Wk18 D3 Repair

Question 1

ECM roles in repair (4)

Answer 1

Scaffold for cells, water, minerals
Reservoir for cytokines, growth factors
Filling the space
Forms basal membranes

Question 2

ECM has 3 types. Consists of fibers. ____ collagen is for ___. ___ collagen is for___.

Answer 2

Basement membrane, Provisional matrix, Connective tissue matrix
Type I, mature scar
Type III, early healing

Question 3

___ binds to many substances. ___ forms basement membranes with Type ___ collagen.

Answer 3

Fibronectin

Laminin, Type IV collagen

Question 4

ECM gels form from ___ and ___. Osteonectin binds collagen to ___, inhibiting __.

Answer 4

Proteoglycan, hyaluronan (turgor)

Hydroxyapatite, angiogenesis

Question 5

___ are Zn proteases that debride tissue that are regulated by ___.

Answer 5

MMP (matrix metalloproteases

TIMP (tissue inhibitors of MP)

Question 6

____ activate cells near wound, controlling ___ and ___. FDF stimulates ___. VEGF stimulates ___. EGF and TGF-alpha stimulate ___.

Answer 6

Growth factors
Tx of growth regulatory genes (myc, fos)
Regulate DNA synthesis and cell division
angiogenesis, vasculogenesis/angiogenesis, fibroblast/epithelial cell division

Question 7

PDGF stimulates ___ and induces ___. Cytokines modulate ___ and ___. TGF-beta induces ___ and ___.

Answer 7

Collagen synth, migration (smooth mus, fibro, monos)
Inflammation and wound healing
Granulation tissue, fibroblasts

Question 8

Do you ever get your collagen back to original strength? Increase in ___ and ___ size, accompanied by

Answer 8

NO, just 70-80%.

Cross-linking, fiber size, devascularization

Question 9

Exuberant granulation = ___. Excess collagen production is ___ or ___
Too much scar can deform, aka ___.
Too little scar can result in __ or ___.

Answer 9

Proud flesh
Hypertrophic scar or keloid
Contracture
Wound dehiscence, ulceration